{"created":"2021-03-01T06:20:42.230575+00:00","id":16135,"links":{},"metadata":{"_buckets":{"deposit":"06bf2813-d528-4274-84ce-50ac3639e275"},"_deposit":{"id":"16135","owners":[],"pid":{"revision_id":0,"type":"depid","value":"16135"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00016135","sets":["453:456","471:537:538:1098"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Nerve Repair by Elongation of the Proximal or Distal Segment Using a Tissue Expander"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"158","bibliographicPageStart":"146","bibliographicVolumeNumber":"113","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nerve defects, after severe injuries or resection of malignant tumors, pose difficult problems. Autologous nerve grafting has been the treatment of choice for the nerve defect；however, donor site morbidity is unavoidable and the regenerating nerve must heal through two coaptation sites. lf a nerve could be elongated safely, it may be repaired with a single coaptation site and donor site morbidity may be avoided. This study, investigating the feasibility of such a procedure, consists of two parts. In part 1, we elongated the nerve proximal to the defect using a tissue expander, and converted that injury to the injury without a gap. In part II, the nerve defect was repaired by elongation of the distal nerve segment. We compared these results with those of conventional nerve grafting. Part 1（proximal nerve elongation）Bilateral median nerves of twenty Japanese White rabbits were used. Median nerve defects were treated by elongation of proximal nerve segment on the right and by grafting on the left. The length of elongation on the right and grafting on the left was identical in each animal, and the animals were divided into 4 groups according to the length of nerve elongation or graft （group A-E： 10 mm elongation, group A－G： mm graft, group B－E： 15 mm elongation, group B-G： 15 mm graft）. After healing, those nerves treated by elongation were compared functionally and histologically tb those treated by grafting. There was no significant difference in each evaluation between group A－E and group A-G. However, the group B－E was significantly inferior to group B-G. Similar results were obtained with nerve repair by proximal nerve elongation using a tissue expander for nerve injury with a smaller defect of less than 10mm （18. 2%）, but, if the defect is larger than that, nerve grafting may provide better results. PartII（distal nerve elongation）The bilateral upper forelimbs of 27 Japanese White rabbits weighing 3. 5－4. 5 Kg were used. Median nerve defects were treated by elongation of distal nerve segment on the right and by grafting on the left. The length of elongation and grafting was identical in each animal, and the animals were divided into 6 groups according to the length of the defect to be repaired （group EIO： 10 mm elongation, group GIO：10mm graft, group E15： 15 mm elongation, group G15： 15 m graft, group E20： 20 mm elongation, group G20： 20mm graft）. The results were evaluated functionally and histologically. The electrophysiological examination included nerve conduction velocity and flexor digitorum muscle contraction force measurement. Histologic evaluation included axon count and fiber analysis. Similar results were obtained, and there were no significant differences between the elongated and grafted groups in 10, 15, and 20 mm groups. The results of this study suggest that distal nerve elongation could be an alternative procedure for repair of nerve injury with a large nerve defect, avoiding the potential donor site morbidity from autogenous nerve.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"103091","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuzaki, Hironori"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松崎, 浩徳"}],"nameIdentifiers":[{"nameIdentifier":"103090","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"113(3)_146-158.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"113(3)_146-158.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/16135/files/113(3)_146-158.pdf"},"version_id":"e25451f5-4dee-4f30-b070-37699026855f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"nerve injury","subitem_subject_scheme":"Other"},{"subitem_subject":"defect","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue expansion","subitem_subject_scheme":"Other"},{"subitem_subject":"autograft","subitem_subject_scheme":"Other"},{"subitem_subject":"神経損傷","subitem_subject_scheme":"Other"},{"subitem_subject":"欠損","subitem_subject_scheme":"Other"},{"subitem_subject":"自家移植","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"欠損を伴う末梢神経損傷の神経延長による修復法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"欠損を伴う末梢神経損傷の神経延長による修復法"},{"subitem_title":"欠損を伴う末梢神経損傷の神経延長による修復法","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1098"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-20"},"publish_date":"2017-02-20","publish_status":"0","recid":"16135","relation_version_is_last":true,"title":["欠損を伴う末梢神経損傷の神経延長による修復法"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:47:42.786449+00:00"}