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We aimed to clarify the difference in biological behavior (grade of malignancy) of high-grade and low-grade carcinomas in the aspect of invasive capacity and cell-proliferative activity. Forty-six high-grade and fifteen low-grade gastric submucosal carcinomas (well or moderately differentiated) were selected for the study. High-grade carcinoma showed smaller (trend) intramucosal spread while greater (P\u003c0.01) area of submucosal invasion and its proportion to the intramucosal spread than low-grade carcinoma. Cell-proliferative activity was estimated by Ki-67 labeling index. For both intramucosal and submucosal area, high-grade carcinoma showed higher (P\u003c0.01, respectively) Ki-67 labeling index than low-grade carcinoma. These results indicate that high-grade carcinoma has a higher invasive capacity and proliferative activity than low-grade carcinoma and suggesting that high-grade carcinoma is a high-grade malignancy and low-grade carcinoma is a low-grade malignancy.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "177339", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Iiri, Takao"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u98ef\u5229, \u5b5d\u96c4"}], "nameIdentifiers": [{"nameIdentifier": "177338", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "113(7-8)_367-375.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "113(7-8)_367-375.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/15965/files/113(7-8)_367-375.pdf"}, "version_id": "b4c8a28b-3d56-461f-8762-acdf3cf84281"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "cellular atypia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastric adenocarcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "biological behavior", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u764c\u306e\u7d30\u80de\u7570\u578b\u5ea6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u80c3\u764c", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u751f\u7269\u5b66\u7684\u614b\u5ea6", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7d30\u80de\u7570\u578b\u5ea6\u5206\u985e\u304b\u3089\u307f\u305f\u5206\u5316\u578b\u80c3\u764c\u306e\u751f\u7269\u5b66\u7684\u60aa\u6027\u5ea6\u306e\u691c\u8a0e : \u9ad8\u30fb\u4f4e\u7570\u578b\u5ea6\u764c\u306esm\u6d78\u6f64\u80fd\u3068\u7d30\u80de\u5897\u6b96\u80fd\u306e\u6bd4\u8f03\u304b\u3089", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7d30\u80de\u7570\u578b\u5ea6\u5206\u985e\u304b\u3089\u307f\u305f\u5206\u5316\u578b\u80c3\u764c\u306e\u751f\u7269\u5b66\u7684\u60aa\u6027\u5ea6\u306e\u691c\u8a0e : \u9ad8\u30fb\u4f4e\u7570\u578b\u5ea6\u764c\u306esm\u6d78\u6f64\u80fd\u3068\u7d30\u80de\u5897\u6b96\u80fd\u306e\u6bd4\u8f03\u304b\u3089"}, {"subitem_title": "\u7d30\u80de\u7570\u578b\u5ea6\u5206\u985e\u304b\u3089\u307f\u305f\u5206\u5316\u578b\u80c3\u764c\u306e\u751f\u7269\u5b66\u7684\u60aa\u6027\u5ea6\u306e\u691c\u8a0e : \u9ad8\u30fb\u4f4e\u7570\u578b\u5ea6\u764c\u306esm\u6d78\u6f64\u80fd\u3068\u7d30\u80de\u5897\u6b96\u80fd\u306e\u6bd4\u8f03\u304b\u3089", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1094"], "permalink_uri": "http://hdl.handle.net/10191/46793", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-24"}, "publish_date": "2017-02-24", "publish_status": "0", "recid": "15965", "relation": {}, "relation_version_is_last": true, "title": ["\u7d30\u80de\u7570\u578b\u5ea6\u5206\u985e\u304b\u3089\u307f\u305f\u5206\u5316\u578b\u80c3\u764c\u306e\u751f\u7269\u5b66\u7684\u60aa\u6027\u5ea6\u306e\u691c\u8a0e : \u9ad8\u30fb\u4f4e\u7570\u578b\u5ea6\u764c\u306esm\u6d78\u6f64\u80fd\u3068\u7d30\u80de\u5897\u6b96\u80fd\u306e\u6bd4\u8f03\u304b\u3089"], "weko_shared_id": null}