@article{oai:niigata-u.repo.nii.ac.jp:00015965, author = {飯利, 孝雄}, issue = {7-8}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Aug}, note = {Differentiated type gastric adenocarcinomas are subclassified into high-grade and low-grade by their cytological atypia. We aimed to clarify the difference in biological behavior (grade of malignancy) of high-grade and low-grade carcinomas in the aspect of invasive capacity and cell-proliferative activity. Forty-six high-grade and fifteen low-grade gastric submucosal carcinomas (well or moderately differentiated) were selected for the study. High-grade carcinoma showed smaller (trend) intramucosal spread while greater (P<0.01) area of submucosal invasion and its proportion to the intramucosal spread than low-grade carcinoma. Cell-proliferative activity was estimated by Ki-67 labeling index. For both intramucosal and submucosal area, high-grade carcinoma showed higher (P<0.01, respectively) Ki-67 labeling index than low-grade carcinoma. These results indicate that high-grade carcinoma has a higher invasive capacity and proliferative activity than low-grade carcinoma and suggesting that high-grade carcinoma is a high-grade malignancy and low-grade carcinoma is a low-grade malignancy.}, pages = {367--375}, title = {細胞異型度分類からみた分化型胃癌の生物学的悪性度の検討 : 高・低異型度癌のsm浸潤能と細胞増殖能の比較から}, volume = {113}, year = {1999} }