{"_buckets": {"deposit": "b2f62fb9-422c-4b98-b7b9-8ca7b0c6f646"}, "_deposit": {"id": "15607", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15607"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00015607", "sets": ["456", "1090"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "TNF-a Induction and Caspase-3 Activation by Verotoxin and Effects of Antibiotics on the Apoptosis－Related Factors"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "62", "bibliographicPageStart": "60", "bibliographicVolumeNumber": "114", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Verotoxin （VT） produced by enterohemorrhagic Escherichia coli （EHEC） is associated with hemolytic uremic syndrome （HUS）. VT induces apoptosis in several kinds of tissues and cell lines such as pediatric tubular cells which are considered to be one of the target tissues for HUS. TNF-α, which is induced by VT or EHEC lipopolysaccharide, stimulates the VT-induced apoptosis. ln this study, we have demonstrated that VT1 caused caspase-3 activation in THP-1 cells, and that azithromycin （AZM）significantly inhibited TNF-α induction by VT1 in peripheral blood mononuclear cells. These data provide a useful in vitro model to investigate the mechanism of VT-induced apoptosis through caspase-3, and the suggestion on a possible use of AZM as an immunomodulator to downregurate TNF－α induction", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "99930", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yoshizawa, Mayuko"}]}, {"nameIdentifiers": [{"nameIdentifier": "99931", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Momose, Takashige"}]}, {"nameIdentifiers": [{"nameIdentifier": "99932", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fukuhara, Tomomi"}]}, {"nameIdentifiers": [{"nameIdentifier": "99933", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hayashi, Masachika"}]}, {"nameIdentifiers": [{"nameIdentifier": "99934", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hori, Yasuhiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "99935", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Morishima, Kazue"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "吉澤, 麻由子"}], "nameIdentifiers": [{"nameIdentifier": "99924", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "百瀬, 能成"}], "nameIdentifiers": [{"nameIdentifier": "99925", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "普久原, 朝海"}], "nameIdentifiers": [{"nameIdentifier": "99926", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "林, 正周"}], "nameIdentifiers": [{"nameIdentifier": "99927", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "堀, 泰彦"}], "nameIdentifiers": [{"nameIdentifier": "99928", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森嶋, 計"}], "nameIdentifiers": [{"nameIdentifier": "99929", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "114(2)_60-62.pdf", "filesize": [{"value": "425.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 425900.0, "url": {"label": "114(2)_60-62.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/15607/files/114(2)_60-62.pdf"}, "version_id": "3bf1a190-6f4d-4c5a-9da3-767eb5ffbd11"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Verotoxin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor necrosis factor-alpha （TNF-a）", "subitem_subject_scheme": "Other"}, {"subitem_subject": "caspase-3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antimicrobial agent", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ベロ毒素", "subitem_subject_scheme": "Other"}, {"subitem_subject": "カスパーゼ-3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗菌剤", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討"}, {"subitem_title": "ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1090"], "permalink_uri": "http://hdl.handle.net/10191/48765", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-17"}, "publish_date": "2017-11-17", "publish_status": "0", "recid": "15607", "relation": {}, "relation_version_is_last": true, "title": ["ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討"], "weko_shared_id": null}