WEKO3
アイテム
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ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討
http://hdl.handle.net/10191/48765
http://hdl.handle.net/10191/48765d67955fd-05a3-4017-bf18-41be1e918744
名前 / ファイル | ライセンス | アクション |
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114(2)_60-62.pdf (425.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-11-17 | |||||
タイトル | ||||||
タイトル | ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Verotoxin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tumor necrosis factor-alpha (TNF-a) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | caspase-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antimicrobial agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ベロ毒素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | カスパーゼ-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 抗菌剤 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | TNF-a Induction and Caspase-3 Activation by Verotoxin and Effects of Antibiotics on the Apoptosis-Related Factors | |||||
著者 |
吉澤, 麻由子
× 吉澤, 麻由子× 百瀬, 能成× 普久原, 朝海× 林, 正周× 堀, 泰彦× 森嶋, 計 |
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著者別名 | ||||||
識別子 | 99930 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yoshizawa, Mayuko | |||||
著者別名 | ||||||
識別子 | 99931 | |||||
識別子Scheme | WEKO | |||||
姓名 | Momose, Takashige | |||||
著者別名 | ||||||
識別子 | 99932 | |||||
識別子Scheme | WEKO | |||||
姓名 | Fukuhara, Tomomi | |||||
著者別名 | ||||||
識別子 | 99933 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hayashi, Masachika | |||||
著者別名 | ||||||
識別子 | 99934 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hori, Yasuhiko | |||||
著者別名 | ||||||
識別子 | 99935 | |||||
識別子Scheme | WEKO | |||||
姓名 | Morishima, Kazue | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Verotoxin (VT) produced by enterohemorrhagic Escherichia coli (EHEC) is associated with hemolytic uremic syndrome (HUS). VT induces apoptosis in several kinds of tissues and cell lines such as pediatric tubular cells which are considered to be one of the target tissues for HUS. TNF-α, which is induced by VT or EHEC lipopolysaccharide, stimulates the VT-induced apoptosis. ln this study, we have demonstrated that VT1 caused caspase-3 activation in THP-1 cells, and that azithromycin (AZM)significantly inhibited TNF-α induction by VT1 in peripheral blood mononuclear cells. These data provide a useful in vitro model to investigate the mechanism of VT-induced apoptosis through caspase-3, and the suggestion on a possible use of AZM as an immunomodulator to downregurate TNF-α induction | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 114, 号 2, p. 60-62, 発行日 2000-02 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |