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Since the expression of voltage-dependent potassium channels\uff08Kv channels\uff09 in cardial myocytes was shown to be affected by thyroid hormone, we examined the mRNA expression of Kv channels both in the atrium and in the ventricle in the hyper and hypothyroid models induced by daily administration of thyroid hormone \uff08T3\uff09 and propylthiouracil \uff08PTU\uff09 in rats, respectively. As we previously demonstrated, the expression of Shaker-type Kv channels \uff08Kv 1.2, Kv 1.4, and Kv 1.5\uff09 was affected by the T 3 or PTU treatment in the atrium and ventricle equally. In contrast, the present study showed apparent induction of mRNA expression of erg and minK Kv channels in the atrium but not in the ventricle by the T 3 treatment. The increase of erg and minK Kv channels may shorten the duration of action potential and the wave length \uff08\uff1drefractory period x conduction velocity\uff09 in the atrium, providing the arrhythmogenic basis for development of atrial fibrillation. The association between hyperthyroidism and atrial fibrillation could be explained by shortening of the action potential duration through induction of erg and minK Kv channel genes in the atrium.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "99923", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ma, Meilei"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u99ac, \u6885\u857e"}], "nameIdentifiers": [{"nameIdentifier": "99922", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "114(2)_53-59.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "114(2)_53-59.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/15606/files/114(2)_53-59.pdf"}, "version_id": "5800f6e1-5069-405f-9fa4-932985475900"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "voltage\uff0ddependent potassium channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "thyroid hormone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "heart", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u81d3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5fc3\u623f\u3068\u5fc3\u5ba4\u306e\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u767a\u73fe\u306b\u5bfe\u3059\u308b\u52b9\u679c", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5fc3\u623f\u3068\u5fc3\u5ba4\u306e\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u767a\u73fe\u306b\u5bfe\u3059\u308b\u52b9\u679c"}, {"subitem_title": "\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5fc3\u623f\u3068\u5fc3\u5ba4\u306e\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u767a\u73fe\u306b\u5bfe\u3059\u308b\u52b9\u679c", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1090"], "permalink_uri": "http://hdl.handle.net/10191/48763", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-11-17"}, "publish_date": "2017-11-17", "publish_status": "0", "recid": "15606", "relation": {}, "relation_version_is_last": true, "title": ["\u7532\u72b6\u817a\u30db\u30eb\u30e2\u30f3\u306e\u5fc3\u623f\u3068\u5fc3\u5ba4\u306e\u96fb\u4f4d\u4f9d\u5b58\u6027\u30ab\u30ea\u30a6\u30e0\u30c1\u30e3\u30cd\u30eb\u767a\u73fe\u306b\u5bfe\u3059\u308b\u52b9\u679c"], "weko_shared_id": null}