{"created":"2021-03-01T06:20:07.798873+00:00","id":15606,"links":{},"metadata":{"_buckets":{"deposit":"35f295e0-4d91-4cf1-9718-c5019d67a9af"},"_deposit":{"id":"15606","owners":[],"pid":{"revision_id":0,"type":"depid","value":"15606"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00015606","sets":["453:456","471:537:538:1090"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Thyroid Hormone on Expression of Voltage-Dependent Potassium Channels in Cardiac Atrium and Ventricle"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"59","bibliographicPageStart":"53","bibliographicVolumeNumber":"114","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In hyperthyroidism, supraventricular premature contraction or atrial fibrillation have been frequently observed but the role of thyroid hormone in the genesis of these arrhythmias is to be determined. Since the expression of voltage-dependent potassium channels（Kv channels） in cardial myocytes was shown to be affected by thyroid hormone, we examined the mRNA expression of Kv channels both in the atrium and in the ventricle in the hyper and hypothyroid models induced by daily administration of thyroid hormone （T3） and propylthiouracil （PTU） in rats, respectively. As we previously demonstrated, the expression of Shaker-type Kv channels （Kv 1.2, Kv 1.4, and Kv 1.5） was affected by the T 3 or PTU treatment in the atrium and ventricle equally. In contrast, the present study showed apparent induction of mRNA expression of erg and minK Kv channels in the atrium but not in the ventricle by the T 3 treatment. The increase of erg and minK Kv channels may shorten the duration of action potential and the wave length （＝refractory period x conduction velocity） in the atrium, providing the arrhythmogenic basis for development of atrial fibrillation. The association between hyperthyroidism and atrial fibrillation could be explained by shortening of the action potential duration through induction of erg and minK Kv channel genes in the atrium.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"99923","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ma, Meilei"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"馬, 梅蕾"}],"nameIdentifiers":[{"nameIdentifier":"99922","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"114(2)_53-59.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"114(2)_53-59.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/15606/files/114(2)_53-59.pdf"},"version_id":"5800f6e1-5069-405f-9fa4-932985475900"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"voltage－dependent potassium channel","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid hormone","subitem_subject_scheme":"Other"},{"subitem_subject":"heart","subitem_subject_scheme":"Other"},{"subitem_subject":"電位依存性カリウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"甲状腺ホルモン","subitem_subject_scheme":"Other"},{"subitem_subject":"心臓","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"甲状腺ホルモンの心房と心室の電位依存性カリウムチャネル発現に対する効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"甲状腺ホルモンの心房と心室の電位依存性カリウムチャネル発現に対する効果"},{"subitem_title":"甲状腺ホルモンの心房と心室の電位依存性カリウムチャネル発現に対する効果","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1090"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-17"},"publish_date":"2017-11-17","publish_status":"0","recid":"15606","relation_version_is_last":true,"title":["甲状腺ホルモンの心房と心室の電位依存性カリウムチャネル発現に対する効果"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:47:14.007905+00:00"}