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  1. 260 大学院医歯学総合研究科(歯)
  2. 10 学術雑誌論文
  3. 10 査読済論文
  1. 0 資料タイプ別
  2. 01 学術雑誌論文

An immunohistochemical study of the expression of heat-shock protein-25 and cell proliferation in the dental pulp and enamel organ during odontogenesis in rat molars

http://hdl.handle.net/10191/1804
http://hdl.handle.net/10191/1804
d1838e09-65e7-400d-965b-7b83eba50a04
名前 / ファイル ライセンス アクション
9_0002.pdf 9_0002.pdf (107.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-05-10
タイトル
タイトル An immunohistochemical study of the expression of heat-shock protein-25 and cell proliferation in the dental pulp and enamel organ during odontogenesis in rat molars
言語
言語 eng
キーワード
主題Scheme Other
主題 Cell Proliferation
キーワード
主題Scheme Other
主題 Cell Differentiation
キーワード
主題Scheme Other
主題 Heat-Shock Proteins
キーワード
主題Scheme Other
主題 Immunohistochemistry
キーワード
主題Scheme Other
主題 Molar
キーワード
主題Scheme Other
主題 Odontogenesis
キーワード
主題Scheme Other
主題 Rats
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakasone, Naohiro

× Nakasone, Naohiro

WEKO 4235

Nakasone, Naohiro

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Yoshie, Hiromasa

× Yoshie, Hiromasa

WEKO 4236

Yoshie, Hiromasa

Search repository
Ohshima, Hayato

× Ohshima, Hayato

WEKO 14

Ohshima, Hayato

Search repository
著者別名
識別子 14
識別子Scheme WEKO
姓名 大島, 勇人
抄録
内容記述タイプ Abstract
内容記述 Objectives: The aim of this study is to clarify the functional significance of heat-shock protein (HSP)-25 during tooth development. Design: We compared the expression of HSP-25 in the dental epithelial and mesenchymal cells with their proliferative activity during odontogenesis in rat molars on postnatal Days 1–100 by immunohistochemistry using anti-HSP-25 and anti-5-bromo-2’-deoxyuridine (BrdU) for cell proliferation assay. Results: On Day one, BrdU-immunoreactive cells were densely located in the inner enamel epithelium in the cervical loop and inter-cusped areas and the dental pulp adjacent to them, whereas HSP-25-immunoractivity (IR) was restricted to the cusped area where odontoblasts and ameloblasts had already differentiated. Subsequently, BrdU-IR shifted in the apical direction to be localized around Hertwig’s epithelial root sheath during Days 5–30, never overlapping with concomitantly apically-shifted HSP-25-IR. On Days 60–100, BrdU-immunoreactive cells were hardly recognizable in the dental pulp, where HSP-25-IR was exclusively localized in the odontoblast layer. Furthermore, the odontoblast- and ameloblast-lineage cells exhibited two steps in the expression of HSP-25 throughout the postnatal stages: first, dental epithelial and pulpal mesenchymal cells showed a weak IR for HSP-25 after the cessation of their proliferative activity, and subsequently odontoblasts and ameloblasts consistently expressed an intense HSP-25-IR. Conclusion: Odontoblast- and ameloblast-lineage cells acquire HSP-25-IR after they complete their cell division, suggesting that this protein acts as a switch between cell proliferation and differentiation during tooth development. The consistent expression of HSP-25-IR in the formative cells may be involved in the maintenance of their functional integrity.
書誌情報 Archives of Oral Biology
en : Archives of Oral Biology

巻 51, 号 5, p. 378-386, 発行日 2006-05
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 00039969
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00548457
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.archoralbio.2005.09.007
権利
権利情報 Elsevier Ltd
著者版フラグ
値 author
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