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Changes of Osteopontin Distribution and Matrix Mineralization during Remodeling in Experimental Bone Formation
http://hdl.handle.net/10191/6194
http://hdl.handle.net/10191/6194948151ca-6d65-4ca7-8b38-fb01f98cb9d5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5_0001.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Changes of Osteopontin Distribution and Matrix Mineralization during Remodeling in Experimental Bone Formation | |||||
| タイトル | ||||||
| タイトル | Changes of Osteopontin Distribution and Matrix Mineralization during Remodeling in Experimental Bone Formation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone remodeling | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mineralization | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Noncollagenous proteins | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteopontin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rhBMP-2 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Irie, Kazuharu
× Irie, Kazuharu× Takeishi, Hideyuki× Tsuruga, Eichi× Sakakura, Yasunori× Nomura, Shuichi× Ozawa, Hidehiro× Ejiri, Sadakazu× Yajima, Toshihiko |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 3973 | |||||
| 姓名 | 竹石, 英之 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 3974 | |||||
| 姓名 | 野村, 修一 | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 3975 | |||||
| 姓名 | 江尻, 貞一 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | When bone is rapidly induced by recombinant human bone morphogenetic protein-2 (rhBMP-2), more noncollagenous proteins (NCPs) are accommodated among the collagen meshwork. These NCPs are then removed, resulting in highly mineralized mature bone. However, few reports have focused on changes in the bone matrix of rhBMP-2-induced bone. In the present study, rhBMP-2 with an artificial carrier was implanted over bone defects in rat calvariae, and changes in the distribution of osteopontin (OPN), the degree of mineralization and speed of bone formation were investigated histochemically and radiographically. Dome-shaped areas of newly formed bone observed at postoperative week 2 were intensely immunoreactive for OPN and intensely labeled with calcein, but were not as radiopaque as the preexisting bone. At postoperative week 8, intense immunoreactivity was detected only on cement lines and in small discrete areas on the flattened domes. The matrix was as radiopaque as, and indistinguishable from, the preexisting bone. Only thin linear labeling of calcein was found on the bone surface. These findings suggest that, in rhBMP-2 induced bone, production of OPN is increased when the rate of bone formation is high, and that OPN produced in the early stage of bone formation is removed during bone remodeling to create a highly mineralized mature bone matrix. | |||||
| 書誌情報 |
Acta histochemica et cytochemica en : Acta histochemica et cytochemica 巻 35, 号 2, p. 113-118, 発行日 2002 |
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| 出版者 | ||||||
| 出版者 | 日本組織細胞化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00445991 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508022 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1267/ahc.35.113 | |||||
| 権利 | ||||||
| 権利情報 | 日本組織細胞化学会 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Irie, Kazuharu, Takeishi, Hideyuki, Tsuruga, Eichi, Sakakura, Yasunori, Nomura, Shuichi, Ozawa, Hidehiro, Ejiri, Sadakazu, Yajima, Toshihiko, 2002, Changes of Osteopontin Distribution and Matrix Mineralization during Remodeling in Experimental Bone Formation: 日本組織細胞化学会, 113–118 p.
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