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アイテム
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孤発性アルツハイマー病への多因子遺伝学的アプローチ
http://hdl.handle.net/10191/48194
http://hdl.handle.net/10191/48194e880a4e0-f12e-4ff7-af68-fc9b432ed2ea
名前 / ファイル | ライセンス | アクション |
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115(5)_176-182.pdf (965.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-11-09 | |||||
タイトル | ||||||
タイトル | 孤発性アルツハイマー病への多因子遺伝学的アプローチ | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 孤発性アルツハイマー病への多因子遺伝学的アプローチ | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sporadic Alzheimer disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polygenic disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apolipoptotein E gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | very low density lipoprotein receptor gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 孤発性アルツハイマー病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 多因子遺伝病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アポリポ蛋白E遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VLDL受容体遺伝子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Polygenic Approaches to Sporadic Alzheimer Disease | |||||
著者 |
奥泉, 薫
× 奥泉, 薫 |
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著者別名 | ||||||
識別子 | 95985 | |||||
識別子Scheme | WEKO | |||||
姓名 | Okuizumi, Kaoru | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neurofibrillary tangles is the characteristic neuropathological manifestation of the disease. Recent investigations have revealed the presence of apolipoprotein E (apoE) in these structures. APOE 4 is one of the genotypes of apoE isoforms. First, the results of this study revealed that APOE 4 is a susceptibility gene for sporadic AD in Japanese, especially with early age of onset. Second, this study focused on the gene for the very low density lipoprotein (VLDL) receptor which is one of the receptors for apoE. Association studies were performed using a polymorphic triplet repeat in the gene for the VLDL receptor. The results indicated the possibility that the VLDL receptor gene is associated with sporadic AD in Japanese, but the association was not significant in the Caucasian population. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 5, p. 176-182, 発行日 2001-05 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |