@article{oai:niigata-u.repo.nii.ac.jp:00014894, author = {奥泉, 薫}, issue = {5}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {May}, note = {Alzheimer disease (AD) is the most common cause of dementia. Accumulation of senile plaques and neurofibrillary tangles is the characteristic neuropathological manifestation of the disease. Recent investigations have revealed the presence of apolipoprotein E (apoE) in these structures. APOE 4 is one of the genotypes of apoE isoforms. First, the results of this study revealed that APOE 4 is a susceptibility gene for sporadic AD in Japanese, especially with early age of onset. Second, this study focused on the gene for the very low density lipoprotein (VLDL) receptor which is one of the receptors for apoE. Association studies were performed using a polymorphic triplet repeat in the gene for the VLDL receptor. The results indicated the possibility that the VLDL receptor gene is associated with sporadic AD in Japanese, but the association was not significant in the Caucasian population.}, pages = {176--182}, title = {孤発性アルツハイマー病への多因子遺伝学的アプローチ}, volume = {115}, year = {2001} }