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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第6号

Stretch-Relaxationによる真皮線維芽細胞の増殖および分化への影響

http://hdl.handle.net/10191/48262
http://hdl.handle.net/10191/48262
0251aab4-c6ee-4602-89e2-ecfedc20949c
名前 / ファイル ライセンス アクション
115(6)_257-270.pdf 115(6)_257-270.pdf (3.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-09
タイトル
タイトル Stretch-Relaxationによる真皮線維芽細胞の増殖および分化への影響
タイトル
言語 en
タイトル Stretch-Relaxationによる真皮線維芽細胞の増殖および分化への影響
言語
言語 jpn
キーワード
主題Scheme Other
主題 dermal fibroblast
キーワード
主題Scheme Other
主題 myofibroblast
キーワード
主題Scheme Other
主題 α-smooth muscle actin
キーワード
主題Scheme Other
主題 TGF-β_1
キーワード
主題Scheme Other
主題 stretch-relaxation
キーワード
主題Scheme Other
主題 真皮線維芽細胞
キーワード
主題Scheme Other
主題 筋線維芽細胞
キーワード
主題Scheme Other
主題 伸展弛緩刺激
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Effect of Stretch-Relaxation on Cell Proliferation of Dermal Fibroblasts and Differentiation into Myofibroblasts
著者 須山, 孝雪

× 須山, 孝雪

WEKO 95813

須山, 孝雪

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著者別名
識別子 95814
識別子Scheme WEKO
姓名 Suyama, Takayuki
抄録
内容記述タイプ Abstract
内容記述 Although dermal fibroblasts receive stretch and relaxation exerted by muscle movement, biological effects of the mechanical force in the cells remains unclear. In the present study to assess effects of stretch and relaxation on cell proliferation and myofibroblast differentiation of dermal fibroblasts, cells were loaded in a biaxial strain device, which was controlled by computer. Cells were subjected to cyclic sigmoidal stretch and relaxation at six cycles/min with 10% maximum change. Immunoblot assay showed that α-smooth muscle actin (α-SMA) expression of cells, either enhanced by transforming growth factor-β_1(TGF-β_1) or not, was decreased by cyclic strain. Flow cytometry suggested that all cells, either stimulated with TG F-β_1 or not, decreased the α-SMA expression in response to the strain. Immunofluorescence microscopy showed that there were star-like, spread cells that were highly positive for α-SMA and spindle cells that were negative or slightly positive for α-SMA, and that the ratio of the former cells to the latter ones was decreased in response to the strain.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 6, p. 257-270, 発行日 2001-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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