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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第9号

脳虚血耐性発現における各種麻酔薬の影響

http://hdl.handle.net/10191/48386
http://hdl.handle.net/10191/48386
3e409e6a-778c-488f-9282-e7e243614817
名前 / ファイル ライセンス アクション
115(9)_421-427.pdf 115(9)_421-427.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-09
タイトル
タイトル 脳虚血耐性発現における各種麻酔薬の影響
タイトル
言語 en
タイトル 脳虚血耐性発現における各種麻酔薬の影響
言語
言語 jpn
キーワード
主題Scheme Other
主題 Ischemic tolerance
キーワード
主題Scheme Other
主題 Cortical spreading depression
キーワード
主題Scheme Other
主題 Anesthetics
キーワード
主題Scheme Other
主題 Membrane depolarization
キーワード
主題Scheme Other
主題 Optical recording
キーワード
主題Scheme Other
主題 虚血耐性
キーワード
主題Scheme Other
主題 麻酔薬
キーワード
主題Scheme Other
主題 膜脱分極
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル The Effects of Anesthetics on Elicitation of Ischemic Tolerance
著者 多賀, 紀一郎

× 多賀, 紀一郎

WEKO 94966

多賀, 紀一郎

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著者別名
識別子 94967
識別子Scheme WEKO
姓名 Taga, Kiichiro
抄録
内容記述タイプ Abstract
内容記述 The effects of cortical spreading depression (CSD) and anesthetics on the induction of ischemic tolerance were investigated. Previous CSD induced tolerance against subsequent ischemic insult. Ketamine, an NMDA antagonist and proven inhibitor of CSD, abolished this preconditioning effect. Volatile anesthetics, halothane, isoflurane and sevoflurane induced suppression of CSD elicitation in a dose dependent manner. With increasing concentrations of each volatile anesthetic, there was dose-related reduction in CSD frequency but not in CSD amplitude. However, volatile anesthetics isoflurane and sevoflurane did not have any effect on the signal transduction pathways that lead to c-fos expression. The differences in propagation of membrane depolarization between neurons that had acquired ischemic tolerance and neurons that had not acquired it were also investigated. In comparison to control slices, propagation was significantly depressed and depolarization was shortened in slices from gerbils subjected to 5 min of ischemia. Slices from gerbils who had acquired ischemic tolerance demonstrated only a slight reduction in propagation. These data indicate that ischemic tolerance attenuates a functional disturbance of synaptic transmission within the hippocampus in gerbils subjected to ischemia.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 9, p. 421-427, 発行日 2001-09
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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