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脳虚血耐性発現における各種麻酔薬の影響
http://hdl.handle.net/10191/48386
http://hdl.handle.net/10191/483863e409e6a-778c-488f-9282-e7e243614817
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
115(9)_421-427.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-09 | |||||
| タイトル | ||||||
| タイトル | 脳虚血耐性発現における各種麻酔薬の影響 | |||||
| タイトル | ||||||
| タイトル | 脳虚血耐性発現における各種麻酔薬の影響 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ischemic tolerance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cortical spreading depression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Anesthetics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Membrane depolarization | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Optical recording | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 虚血耐性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 麻酔薬 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 膜脱分極 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | The Effects of Anesthetics on Elicitation of Ischemic Tolerance | |||||
| 著者 |
多賀, 紀一郎
× 多賀, 紀一郎 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 94967 | |||||
| 姓名 | Taga, Kiichiro | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of cortical spreading depression (CSD) and anesthetics on the induction of ischemic tolerance were investigated. Previous CSD induced tolerance against subsequent ischemic insult. Ketamine, an NMDA antagonist and proven inhibitor of CSD, abolished this preconditioning effect. Volatile anesthetics, halothane, isoflurane and sevoflurane induced suppression of CSD elicitation in a dose dependent manner. With increasing concentrations of each volatile anesthetic, there was dose-related reduction in CSD frequency but not in CSD amplitude. However, volatile anesthetics isoflurane and sevoflurane did not have any effect on the signal transduction pathways that lead to c-fos expression. The differences in propagation of membrane depolarization between neurons that had acquired ischemic tolerance and neurons that had not acquired it were also investigated. In comparison to control slices, propagation was significantly depressed and depolarization was shortened in slices from gerbils subjected to 5 min of ischemia. Slices from gerbils who had acquired ischemic tolerance demonstrated only a slight reduction in propagation. These data indicate that ischemic tolerance attenuates a functional disturbance of synaptic transmission within the hippocampus in gerbils subjected to ischemia. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 9, p. 421-427, 発行日 2001-09 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
