{"_buckets": {"deposit": "81356f39-0b59-4229-a65d-dd4c30939feb"}, "_deposit": {"id": "14064", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14064"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014064", "sets": ["456", "1058"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Hippocampal CA3 Pyramidal Cell-specific and Efficient Cre Mediated Recombination in the C57BL/6 Mouse Line"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "492", "bibliographicPageStart": "482", "bibliographicVolumeNumber": "116", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The hippocampal CA 3 region is thought to be an important place for formation of learning and memory. To understand the role of the hippocampal CA 3 region in the higher brain functions, we attempted to make a conditional targeting system specific for the hippocampal CA 3 region using the Cre/loxP recombination system. The CA 3 specific expression of Cre recombinase was attained by inserting Cre gene into the glutamate receptor γ 1 subunit (GluR γ 1) gene that was predominantly expressed in the CA 3 pyramidal neurons. Then we generated a mutant mouse line, γ 1 CreN from C57BL/6 ES cells, which is most suitable for behavioral studies. In the γ 1 CreN line, functional Cre recombinase activity was observed to be restricted almost only to the hippocampal CA 3 pyramidal neurons starting from newborn period to adulthood. The efficacy of Cre-mediated recombination was as high as 100 % in the pyramidal cells of the hippocampal CA 3 region both at postnatal ages 8 days and 10 weeks. This γ 1 CreN line is expected to become a useful tool for studying molecular functions of the hippocampal CA 3 region.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "明石, 馨"}], "nameIdentifiers": [{"nameIdentifier": "91652", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000142129.pdf", "filesize": [{"value": "4.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4500000.0, "url": {"label": "KJ00000142129.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14064/files/KJ00000142129.pdf"}, "version_id": "83ce1aae-9d68-4a6c-bb35-4de78f5ccda2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "hippocampal CA 3 region", "subitem_subject_scheme": "Other"}, {"subitem_subject": "conditional targeting system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cre-loxP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GluRγ 1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "C57BL 6 ES cell", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出"}, {"subitem_title": "海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1058"], "permalink_uri": "http://hdl.handle.net/10191/3487", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "14064", "relation": {}, "relation_version_is_last": true, "title": ["海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出"], "weko_shared_id": null}