{"created":"2021-03-01T06:18:28.459405+00:00","id":14064,"links":{},"metadata":{"_buckets":{"deposit":"81356f39-0b59-4229-a65d-dd4c30939feb"},"_deposit":{"id":"14064","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14064"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014064","sets":["453:456","471:537:538:1058"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hippocampal CA3 Pyramidal Cell-specific and Efficient Cre Mediated Recombination in the C57BL/6 Mouse Line"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"492","bibliographicPageStart":"482","bibliographicVolumeNumber":"116","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The hippocampal CA 3 region is thought to be an important place for formation of learning and memory. To understand the role of the hippocampal CA 3 region in the higher brain functions, we attempted to make a conditional targeting system specific for the hippocampal CA 3 region using the Cre/loxP recombination system. The CA 3 specific expression of Cre recombinase was attained by inserting Cre gene into the glutamate receptor γ 1 subunit (GluR γ 1) gene that was predominantly expressed in the CA 3 pyramidal neurons. Then we generated a mutant mouse line, γ 1 CreN from C57BL/6 ES cells, which is most suitable for behavioral studies. In the γ 1 CreN line, functional Cre recombinase activity was observed to be restricted almost only to the hippocampal CA 3 pyramidal neurons starting from newborn period to adulthood. The efficacy of Cre-mediated recombination was as high as 100 % in the pyramidal cells of the hippocampal CA 3 region both at postnatal ages 8 days and 10 weeks. This γ 1 CreN line is expected to become a useful tool for studying molecular functions of the hippocampal CA 3 region.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"明石, 馨"}],"nameIdentifiers":[{"nameIdentifier":"91652","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00000142129.pdf","filesize":[{"value":"4.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000142129.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14064/files/KJ00000142129.pdf"},"version_id":"83ce1aae-9d68-4a6c-bb35-4de78f5ccda2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hippocampal CA 3 region","subitem_subject_scheme":"Other"},{"subitem_subject":"conditional targeting system","subitem_subject_scheme":"Other"},{"subitem_subject":"Cre-loxP","subitem_subject_scheme":"Other"},{"subitem_subject":"GluRγ 1","subitem_subject_scheme":"Other"},{"subitem_subject":"C57BL 6 ES cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出"},{"subitem_title":"海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1058"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"14064","relation_version_is_last":true,"title":["海馬CA3錐体細胞特異的遺伝子組換え系の確立 : C57BL/6 系統 ES 細胞からのマウス作出"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:16.731765+00:00"}