{"_buckets": {"deposit": "98ea558b-b50c-4078-ba9b-54d04a6569fc"}, "_deposit": {"id": "14007", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14007"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014007"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Mechanism of Autoimmunity in Human Polymyositis, Based on the Experimental Allergic Myositis Induced by Inoculating Dendritic Cells"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "565", "bibliographicPageStart": "546", "bibliographicVolumeNumber": "116", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Polymyositis(PM) is an inflammatory muscle disease caused by autoimmune dysfunction, and considered to be caused by cytotoxic CD 8 T cells. To date no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DCs) presenting peptides that are expected to match the binding anchor motif of H-2Kd(BALB/c). We selected peptides that are abundantly expressed in skeletal muscle as the candidate antigens. Only when we inoculated syngeneic bone-marrow-derived DCs presenting pyruvate kinase M1/M2 peptide 464-472 in BALB/c mice, 41.7% of the mice (EAM) developed pathological changes in skeletal muscle compatible to human-PM. Under other conditions (when we inoculated DCs presenting sodium channel protein (skeletal muscle alpha-subunit) peptide 1264-1274 into BALB/c or C57BL mice, or DCs presenting pyruvate kinase M1/M2 peptide into C57BL/6 mice, there were no necrotizing and inflammatory lesions. Induction of EAM in the same manner as above also induced CTL activity against P815 cells with the pyruvate kinase M1/M2 peptide and syngeneic differentiated-cultured-myotubes without peptides by the chromium release assay. Consistent with the similarity of the binding anchor motifs of H-2Kd (BALB/c) and HLA A*2402, we found that pyruvate kinase M1/M2 peptide-specific and interferon \u03b3-producing T lymphocytes existed in peripheral blood of human-PM with the HLA A*2402 allele by the enzyme linked immunospot (ELISPOT) assay. Therefore we concluded that pyruvate kinase M1/M2 peptide is a candidate autoantigen not only in BALB/c-EAM but also in human-PM with the HLA A*2402 allele.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6cb3\u5185, \u6cc9"}], "nameIdentifiers": [{"nameIdentifier": "91319", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000142247.pdf", "filesize": [{"value": "4.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4700000.0, "url": {"label": "KJ00000142247.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14007/files/KJ00000142247.pdf"}, "version_id": "24246c73-184e-4c31-a49d-8933778c9d4c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Polymyositis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Dendritic cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MHC-binding anchor motif", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T cell epitope", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cross-priming", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30d2\u30c8\u591a\u767a\u7b4b\u708e\u767a\u75c7\u6a5f\u69cb\u306e\u7814\u7a76 : \u6a39\u72b6\u7d30\u80de\u79fb\u690d\u306b\u3088\u308b\u5b9f\u9a13\u7684\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u7b4b\u708e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3092\u3082\u3068\u306b", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30d2\u30c8\u591a\u767a\u7b4b\u708e\u767a\u75c7\u6a5f\u69cb\u306e\u7814\u7a76 : \u6a39\u72b6\u7d30\u80de\u79fb\u690d\u306b\u3088\u308b\u5b9f\u9a13\u7684\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u7b4b\u708e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3092\u3082\u3068\u306b"}, {"subitem_title": "\u30d2\u30c8\u591a\u767a\u7b4b\u708e\u767a\u75c7\u6a5f\u69cb\u306e\u7814\u7a76 : \u6a39\u72b6\u7d30\u80de\u79fb\u690d\u306b\u3088\u308b\u5b9f\u9a13\u7684\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u7b4b\u708e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3092\u3082\u3068\u306b", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1057"], "permalink_uri": "http://hdl.handle.net/10191/3973", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "14007", "relation": {}, "relation_version_is_last": true, "title": ["\u30d2\u30c8\u591a\u767a\u7b4b\u708e\u767a\u75c7\u6a5f\u69cb\u306e\u7814\u7a76 : \u6a39\u72b6\u7d30\u80de\u79fb\u690d\u306b\u3088\u308b\u5b9f\u9a13\u7684\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u7b4b\u708e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3092\u3082\u3068\u306b"], "weko_shared_id": null}