{"_buckets": {"deposit": "98ea558b-b50c-4078-ba9b-54d04a6569fc"}, "_deposit": {"id": "14007", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14007"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014007", "sets": ["456", "1057"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Mechanism of Autoimmunity in Human Polymyositis, Based on the Experimental Allergic Myositis Induced by Inoculating Dendritic Cells"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "565", "bibliographicPageStart": "546", "bibliographicVolumeNumber": "116", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Polymyositis(PM) is an inflammatory muscle disease caused by autoimmune dysfunction, and considered to be caused by cytotoxic CD 8 T cells. To date no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DCs) presenting peptides that are expected to match the binding anchor motif of H-2Kd(BALB/c). We selected peptides that are abundantly expressed in skeletal muscle as the candidate antigens. Only when we inoculated syngeneic bone-marrow-derived DCs presenting pyruvate kinase M1/M2 peptide 464-472 in BALB/c mice, 41.7% of the mice (EAM) developed pathological changes in skeletal muscle compatible to human-PM. Under other conditions (when we inoculated DCs presenting sodium channel protein (skeletal muscle alpha-subunit) peptide 1264-1274 into BALB/c or C57BL mice, or DCs presenting pyruvate kinase M1/M2 peptide into C57BL/6 mice, there were no necrotizing and inflammatory lesions. Induction of EAM in the same manner as above also induced CTL activity against P815 cells with the pyruvate kinase M1/M2 peptide and syngeneic differentiated-cultured-myotubes without peptides by the chromium release assay. Consistent with the similarity of the binding anchor motifs of H-2Kd (BALB/c) and HLA A*2402, we found that pyruvate kinase M1/M2 peptide-specific and interferon γ-producing T lymphocytes existed in peripheral blood of human-PM with the HLA A*2402 allele by the enzyme linked immunospot (ELISPOT) assay. Therefore we concluded that pyruvate kinase M1/M2 peptide is a candidate autoantigen not only in BALB/c-EAM but also in human-PM with the HLA A*2402 allele.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "河内, 泉"}], "nameIdentifiers": [{"nameIdentifier": "91319", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000142247.pdf", "filesize": [{"value": "4.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4700000.0, "url": {"label": "KJ00000142247.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14007/files/KJ00000142247.pdf"}, "version_id": "24246c73-184e-4c31-a49d-8933778c9d4c"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Polymyositis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Dendritic cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MHC-binding anchor motif", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T cell epitope", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cross-priming", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに"}, {"subitem_title": "ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1057"], "permalink_uri": "http://hdl.handle.net/10191/3973", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "14007", "relation": {}, "relation_version_is_last": true, "title": ["ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに"], "weko_shared_id": null}