{"created":"2021-03-01T06:18:24.695594+00:00","id":14007,"links":{},"metadata":{"_buckets":{"deposit":"98ea558b-b50c-4078-ba9b-54d04a6569fc"},"_deposit":{"id":"14007","owners":[],"pid":{"revision_id":0,"type":"depid","value":"14007"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00014007","sets":["453:456","471:537:538:1057"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mechanism of Autoimmunity in Human Polymyositis, Based on the Experimental Allergic Myositis Induced by Inoculating Dendritic Cells"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"565","bibliographicPageStart":"546","bibliographicVolumeNumber":"116","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Polymyositis(PM) is an inflammatory muscle disease caused by autoimmune dysfunction, and considered to be caused by cytotoxic CD 8 T cells. To date no autoantigens have been identified. We attempted to induce an experimental allergic myositis (EAM) in BALB/c mice by inoculating syngeneic dendritic cells (DCs) presenting peptides that are expected to match the binding anchor motif of H-2Kd(BALB/c). We selected peptides that are abundantly expressed in skeletal muscle as the candidate antigens. Only when we inoculated syngeneic bone-marrow-derived DCs presenting pyruvate kinase M1/M2 peptide 464-472 in BALB/c mice, 41.7% of the mice (EAM) developed pathological changes in skeletal muscle compatible to human-PM. Under other conditions (when we inoculated DCs presenting sodium channel protein (skeletal muscle alpha-subunit) peptide 1264-1274 into BALB/c or C57BL mice, or DCs presenting pyruvate kinase M1/M2 peptide into C57BL/6 mice, there were no necrotizing and inflammatory lesions. Induction of EAM in the same manner as above also induced CTL activity against P815 cells with the pyruvate kinase M1/M2 peptide and syngeneic differentiated-cultured-myotubes without peptides by the chromium release assay. Consistent with the similarity of the binding anchor motifs of H-2Kd (BALB/c) and HLA A*2402, we found that pyruvate kinase M1/M2 peptide-specific and interferon γ-producing T lymphocytes existed in peripheral blood of human-PM with the HLA A*2402 allele by the enzyme linked immunospot (ELISPOT) assay. Therefore we concluded that pyruvate kinase M1/M2 peptide is a candidate autoantigen not only in BALB/c-EAM but also in human-PM with the HLA A*2402 allele.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河内, 泉"}],"nameIdentifiers":[{"nameIdentifier":"91319","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00000142247.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000142247.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/14007/files/KJ00000142247.pdf"},"version_id":"24246c73-184e-4c31-a49d-8933778c9d4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Polymyositis","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendritic cells","subitem_subject_scheme":"Other"},{"subitem_subject":"MHC-binding anchor motif","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell epitope","subitem_subject_scheme":"Other"},{"subitem_subject":"Cross-priming","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに"},{"subitem_title":"ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1057"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"14007","relation_version_is_last":true,"title":["ヒト多発筋炎発症機構の研究 : 樹状細胞移植による実験的アレルギー性筋炎モデルマウスの解析をもとに"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:46:15.828419+00:00"}