{"_buckets": {"deposit": "dd8cbb08-f0c2-4d3a-a5ac-53db0ea861d7"}, "_deposit": {"id": "13212", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "13212"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00013212", "sets": ["456", "1041"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Monitoring of Serum 5-FU Concentrations During Pharmacokinetic Modulating Chemotherapy for Recurrent Colorectal Cancer"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "161", "bibliographicPageStart": "157", "bibliographicVolumeNumber": "118", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "【目的】Pharmacokinetic modulating chemotherapy (PMC療法)は血清5-FU濃度を高濃度に保つことにより,高い抗腫瘍効果を得る治療法である.本研究の目的は,PMC療法中の血清5-FU濃度の推移を明らかにすることである.【方法】対象は大腸癌術後再発7症例であり,全例が評価可能な再発病変を有していた.原発部位は結腸5例,直腸2例であり,再発部位は肝+肺3例,肝+肺+リンパ節1例,腹膜単独2例,リンパ節単独1例であった.PMC療法(週1回の5-FU600～900mg/m^2/24h持続静注およびUFT400mg/dayの週5～7日間経口投与)を施行し,5-FUの24h持続静注時の血清5-FU濃度を測定した(HPLC法).【成績】7症例におけるPMC療法の施行期間は6～15か月(中央値10か月)であった.PR5例,NC2例(内1例MR)であり,6例で腫瘍が縮小した.肝+肺再発の2例,肝+肺+リンパ節再発の1例および腹膜単独再発の2例ではPRが得られた.Grade2以上の副作用は認められなかった.PMC療法(5-FU投与量600mg/m^2/24h)中の血清5-FU濃度は,日中低く夜間に最高値(153～313ng/ml,中央値240ng/ml)となった.【結語】大腸癌術後再発に対しPMC療法は有効である.PMC療法中の血清5-FU濃度の推移は,日中低く夜間に最高値となる.PMC療法の有効性は,夜間の高い血清5-FU濃度によるものと考えられる.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宗岡, 克樹"}], "nameIdentifiers": [{"nameIdentifier": "87125", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "白井, 良夫"}], "nameIdentifiers": [{"nameIdentifier": "87126", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "横山, 直行"}], "nameIdentifiers": [{"nameIdentifier": "87127", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "若井, 俊文"}], "nameIdentifiers": [{"nameIdentifier": "87128", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "畠山, 勝義"}], "nameIdentifiers": [{"nameIdentifier": "87129", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須田, 剛士"}], "nameIdentifiers": [{"nameIdentifier": "87130", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青柳, 豊"}], "nameIdentifiers": [{"nameIdentifier": "87131", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004351504.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "KJ00004351504.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/13212/files/KJ00004351504.pdf"}, "version_id": "4efb8c87-7b59-4c8a-96da-00a3b244b93d"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pharmacokinetic Modulating Chemotherapy (PMC療法)施行中の血清5-FU濃度 : 大腸癌術後再発症例における検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pharmacokinetic Modulating Chemotherapy (PMC療法)施行中の血清5-FU濃度 : 大腸癌術後再発症例における検討"}, {"subitem_title": "Pharmacokinetic Modulating Chemotherapy (PMC療法)施行中の血清5-FU濃度 : 大腸癌術後再発症例における検討", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1041"], "permalink_uri": "http://hdl.handle.net/10191/2841", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "13212", "relation": {}, "relation_version_is_last": true, "title": ["Pharmacokinetic Modulating Chemotherapy (PMC療法)施行中の血清5-FU濃度 : 大腸癌術後再発症例における検討"], "weko_shared_id": null}