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アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について
http://hdl.handle.net/10191/3266
http://hdl.handle.net/10191/32661668e554-3337-432c-afb6-bc45ee63f6f6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004300072.pdf (1.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について | |||||
| タイトル | ||||||
| タイトル | アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | acetaminophen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hepatotoxicity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CYP2E1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GSTM1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polymorphism | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Acetaminophen Hepatotoxicity and, CYP2E1 and GSTM1 Genetic Polymorphisms in the Japanese Population | |||||
| 著者 |
坂爪, 重明
× 坂爪, 重明 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Genetic polymorphisms at -1293, -1053, -352, -333, -71, 1132 and 7632 of CYP2E1 and nonnull or null type of GSTM1 were examined in 101 Japanese patients given 0.3-1.35g of acetaminophen(APAP) orally in Niigata University Medical Hospital and 125 healthy Japanese volunteers using PCR-based analysis. In the CYP2E1 and GSTM1 genotype frequencies there was no dif-ference between the patients and the volunteers(p>0.1). The sites of -71 and 1132 were monomorphic in 226 DNA samples. For Pst I(-1293)/Rsa I(-1053) and Dra I(7632) sites of the CYP2E1 gene, haplotype frequencies were also estimated by a method with Arlequin Software. The outcome of the calculation showed that all variant alleles (CYP2E1^*5), recognized by the Pst I, but not by the Rsa I, carried variant allele A of Dra I sites. At the Dra I sites, 65% of all A alleles carried CYP2E1^*5 allele, which could possibly affect its transcription. Seven of the 101 patients were caused drug-induced liver damage by the APAP ingestion. Of the seven patients, one had developed serious liver damage. There was no difference between hepatotoxicity (+) -patients(n=7) and hepatotoxicity (-) -patients(n=94) either in the CYP2E1 genotype frequencies(p>0.06) or in GSTM1(p=0.84). However, the sample number of the hepatotoxicity (+) -patients is too small to evaluate the association between genotypic differences and liver damage by acetaminophen. Of interest was the observation that the genotype CYP2El^*5/^*5was not found in the hepatotoxicity(+) -patients, but was found in three of the hepatotoxicity(-) -patients. In this study, no association was found between CYP2E1 and GSTM1 polymorphisms examined and APAP-induced liver damage. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 119, 号 2, p. 95-105, 発行日 2005-02 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
