{"created":"2021-03-01T06:16:58.310941+00:00","id":12679,"links":{},"metadata":{"_buckets":{"deposit":"a699f3b6-c0df-4b0b-b7e1-79857e89841b"},"_deposit":{"id":"12679","owners":[],"pid":{"revision_id":0,"type":"depid","value":"12679"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00012679","sets":["453:456","471:537:538:1030"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Acetaminophen Hepatotoxicity and, CYP2E1 and GSTM1 Genetic Polymorphisms in the Japanese Population"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"105","bibliographicPageStart":"95","bibliographicVolumeNumber":"119","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Genetic polymorphisms at -1293, -1053, -352, -333, -71, 1132 and 7632 of CYP2E1 and nonnull or null type of GSTM1 were examined in 101 Japanese patients given 0.3-1.35g of acetaminophen(APAP) orally in Niigata University Medical Hospital and 125 healthy Japanese volunteers using PCR-based analysis. In the CYP2E1 and GSTM1 genotype frequencies there was no dif-ference between the patients and the volunteers(p>0.1). The sites of -71 and 1132 were monomorphic in 226 DNA samples. For Pst I(-1293)/Rsa I(-1053) and Dra I(7632) sites of the CYP2E1 gene, haplotype frequencies were also estimated by a method with Arlequin Software. The outcome of the calculation showed that all variant alleles (CYP2E1^*5), recognized by the Pst I, but not by the Rsa I, carried variant allele A of Dra I sites. At the Dra I sites, 65% of all A alleles carried CYP2E1^*5 allele, which could possibly affect its transcription. Seven of the 101 patients were caused drug-induced liver damage by the APAP ingestion. Of the seven patients, one had developed serious liver damage. There was no difference between hepatotoxicity (+) -patients(n=7) and hepatotoxicity (-) -patients(n=94) either in the CYP2E1 genotype frequencies(p>0.06) or in GSTM1(p=0.84). However, the sample number of the hepatotoxicity (+) -patients is too small to evaluate the association between genotypic differences and liver damage by acetaminophen. Of interest was the observation that the genotype CYP2El^*5/^*5was not found in the hepatotoxicity(+) -patients, but was found in three of the hepatotoxicity(-) -patients. In this study, no association was found between CYP2E1 and GSTM1 polymorphisms examined and APAP-induced liver damage.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂爪, 重明"}],"nameIdentifiers":[{"nameIdentifier":"84408","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-07"}],"displaytype":"detail","filename":"KJ00004300072.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004300072.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/12679/files/KJ00004300072.pdf"},"version_id":"f944497b-389a-4d16-96a9-01fcf333951b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"acetaminophen","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatotoxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP2E1","subitem_subject_scheme":"Other"},{"subitem_subject":"GSTM1","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について"},{"subitem_title":"アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1030"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"12679","relation_version_is_last":true,"title":["アセトアミノフェンによる肝障害と日本人におけるCYP2E1,GSTM1の遺伝子多型との関連について"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:45:27.413646+00:00"}