{"_buckets": {"deposit": "387a2663-d7f0-445c-9843-d454e68c0d4f"}, "_deposit": {"id": "11397", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "11397"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00011397", "sets": ["456", "995"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Expression of Liver X Receptor αin Human monocyte-derived Macrophages and Lipid Metabolism"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "48", "bibliographicPageStart": "37", "bibliographicVolumeNumber": "122", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Liiver X receptorα(LXRα)は核内受容体スーパーファミリーのひとつであり,主にマクロファージに発現して脂質代謝に関わる.本研究ではGM-CSFの存在下で分化したヒト単球由来マクロファージ(GM-Mφ)とM-CSFの存在下で分化したマクロファージ(M-Mφ)を用いて,LXRαと脂質関連分子の発現について検討を行った.培養5日後のGM-MφはM-Mφに比べてLXRαとABCA1陽性細胞が有意に多く,LXRαの蛋白発現が高かった.培養5日目に酸化LDLを添加し,その48時間後のGM-MφはM-Mφに比べ脂質の取り込みは有意に増加した.以上の結果から,GM-MφはM-Mφに比べ脂質代謝により大きく関与していると考えられた.GM-MφはLLXRαの合成リガンドTO901317によってLXRαとABCA1の蛋白発現が増加した.GM-MφにLPSやZymosanを添加するとLIXRαやABCA1の他,MSR-Aの発現も有意に減少した.さらにGM-MφにLPSやZymosanを添加し,さらに酸化LDLを添加すると5日後に脂質の著しい蓄積が見られた.以上の成績からLLXRαはマクロファージの炎症反応と脂質代謝に重要な役割を果たしており,LPSやZymosanによるLXRαおよびABCA1の発現低下が泡沫細胞の形成に関与すると考えられた.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "77496", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kazawa, Toshihiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, 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{"subitem_subject": "脂質代謝", "subitem_subject_scheme": "Other"}, {"subitem_subject": "炎症", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究"}, {"subitem_title": "ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "995"], "permalink_uri": "http://hdl.handle.net/10191/32982", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-11"}, "publish_date": "2015-08-11", "publish_status": "0", "recid": "11397", "relation": {}, 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