{"created":"2021-03-01T06:15:35.945439+00:00","id":11397,"links":{},"metadata":{"_buckets":{"deposit":"387a2663-d7f0-445c-9843-d454e68c0d4f"},"_deposit":{"id":"11397","owners":[],"pid":{"revision_id":0,"type":"depid","value":"11397"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00011397","sets":["453:456","471:537:538:995"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Expression of Liver X Receptor αin Human monocyte-derived Macrophages and Lipid Metabolism"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"48","bibliographicPageStart":"37","bibliographicVolumeNumber":"122","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Liiver X receptorα(LXRα)は核内受容体スーパーファミリーのひとつであり,主にマクロファージに発現して脂質代謝に関わる.本研究ではGM-CSFの存在下で分化したヒト単球由来マクロファージ(GM-Mφ)とM-CSFの存在下で分化したマクロファージ(M-Mφ)を用いて,LXRαと脂質関連分子の発現について検討を行った.培養5日後のGM-MφはM-Mφに比べてLXRαとABCA1陽性細胞が有意に多く,LXRαの蛋白発現が高かった.培養5日目に酸化LDLを添加し,その48時間後のGM-MφはM-Mφに比べ脂質の取り込みは有意に増加した.以上の結果から,GM-MφはM-Mφに比べ脂質代謝により大きく関与していると考えられた.GM-MφはLLXRαの合成リガンドTO901317によってLXRαとABCA1の蛋白発現が増加した.GM-MφにLPSやZymosanを添加するとLIXRαやABCA1の他,MSR-Aの発現も有意に減少した.さらにGM-MφにLPSやZymosanを添加し,さらに酸化LDLを添加すると5日後に脂質の著しい蓄積が見られた.以上の成績からLLXRαはマクロファージの炎症反応と脂質代謝に重要な役割を果たしており,LPSやZymosanによるLXRαおよびABCA1の発現低下が泡沫細胞の形成に関与すると考えられた.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"77496","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kazawa, Toshihiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_relation_31":{"attribute_name":"異版である","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110007146385","subitem_relation_type_select":"URI"}}]},"item_7_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加澤, 敏広"}],"nameIdentifiers":[{"nameIdentifier":"77495","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"110007146385.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110007146385.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/11397/files/110007146385.pdf"},"version_id":"053c9542-58ab-412e-bb4f-ac8eebee9eb6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LXRα","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト単球由来マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"GM-CSF","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究"},{"subitem_title":"ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","995"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-11"},"publish_date":"2015-08-11","publish_status":"0","recid":"11397","relation_version_is_last":true,"title":["ヒト単球由来マクロファージにおけるliver X receptor α の発現と脂質代謝に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:44.953352+00:00"}