{"_buckets": {"deposit": "ed6ece72-ee38-4f59-95ee-5c7081c2af36"}, "_deposit": {"id": "10556", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10556"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010556"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Caspase-3 Dependent Proteolytic Cleavage of TDP-43 After Focal Cerebral Ischemia in Rats"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "562", "bibliographicPageStart": "552", "bibliographicVolumeNumber": "123", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "TARDNA\u7d50\u5408\u86cb\u767d-43 (TDP-43) \u306f, \u30e6\u30d3\u30ad\u30c1\u30f3\u967d\u6027\u5c01\u5165\u4f53\u3092\u4f34\u3046\u524d\u982d\u5074\u982d\u8449\u5909\u6027\u75c7 (FTLD-U) \u3084\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7 (ALS) \u306b\u304a\u3051\u308b\u795e\u7d4c\u7d30\u80de\u3084\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u7d30\u80de\u8cea\u5185\u30fb\u6838\u5185\u5c01\u5165\u4f53\u306e\u4e3b\u8981\u306a\u69cb\u6210\u6210\u5206\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b. \u307e\u305f FTLD-U\u3084 ALS\u306e\u60a3\u8005\u5256\u691c\u8133\u30fb\u810a\u9ac4\u306b\u304a\u3051\u308bTDP-43\u86cb\u767d\u306f, \u9ad8\u5ea6\u306b\u30ea\u30f3\u9178\u5316\u3055\u308c\u308b\u3053\u3068\u3084, \u6838\u5c40\u5728\u30b7\u30b0\u30ca\u30eb\u3092\u6b20\u304fC\u672b\u7aef\u65ad\u7247 (25kDa) \u306b\u5207\u65ad\u3055\u308c, \u3055\u3089\u306b\u4e0d\u6eb6\u5316\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u308b. \u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089, TDP-43\u306f\u795e\u7d4c\u306e\u6a5f\u80fd\u7dad\u6301\u3084\u751f\u5b58\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u308b. \u672c\u7814\u7a76\u3067\u306f\u5c40\u6240\u8133\u865a\u8840\u306b\u304a\u3051\u308bTDP-43\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081, \u865a\u8840\u5f8c\u306e\u30e9\u30c3\u30c8\u8133\u3092\u7528\u3044\u3066TDP-43\u306e\u767a\u73fe\u3092\u7d4c\u6642\u7684\u306b\u89e3\u6790\u3057\u305f. \u52d5\u7269\u30e2\u30c7\u30eb\u3068\u3057\u3066\u585e\u6813\u7cf8\u306b\u3088\u308b90\u5206\u9593\u306e\u4e00\u904e\u6027\u4e2d\u5927\u8133\u52d5\u8108\u9589\u585e\u3092\u884c\u3063\u305f. \u518d\u6f45\u6d4124\u6642\u9593\u5f8c, \u5168\u9577\u578bTDP-43 (43kDa) \u306f, \u865a\u8840\u76ae\u8cea\u306b\u304a\u3044\u3066sham\u624b\u8853\u7fa4\u3068\u6bd4\u3079\u6e1b\u5c11\u3057\u3066\u3044\u305f\u304c (P \u003c0.01), \u4e0d\u6eb6\u5316\u3084\u30ea\u30f3\u9178\u5316\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f. \u307e\u305f\u865a\u8840\u76ae\u8cea\u3067\u306f, \u53ef\u6eb6\u6027C\u672b\u7aef\u65ad\u7247 (25kDa) \u306fsham\u624b\u8853\u7fa4\u3068\u6bd4\u3079\u3066, \u8457\u5897\u3057\u3066\u3044\u305f (P \u003c0.01). 25kDaC\u672b\u7aef\u65ad\u7247\u306f\u7d30\u80de\u8cea\u5206\u753b\u306b\u306e\u307f\u8a8d\u3081\u305f. \u514d\u75ab\u7d44\u7e54\u5b66\u7684\u89e3\u6790\u306b\u3066, sham\u624b\u8853\u7fa4\u3067\u306fTDP-43\u306f\u795e\u7d4c\u7d30\u80de\u306e\u6838\u306b\u5c40\u5728\u3057\u3066\u3044\u305f\u306e\u306b\u5bfe\u3057, \u865a\u8840\u518d\u6f45\u6d41\u306e24\u6642\u9593\u5f8c\u306b\u306f, TDP-43\u306f\u7d30\u80de\u8cea\u306b\u3082\u5c40\u5728\u304c\u898b\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f. caspase-3\u9078\u629e\u7684\u963b\u5bb3\u5264\u306f, \u865a\u8840\u518d\u6f45\u6d41\u306e24\u6642\u9593\u5f8c\u306b\u304a\u3051\u308bTDP-43\u306e\u9650\u5b9a\u5206\u89e3\u3092\u6291\u5236\u3057\u305f (P \u003c0.01). \u3055\u3089\u306b, \u865a\u8840\u4e2d\u306e\u4f4e\u4f53\u6e29\u7642\u6cd5 (30\u2103)\u306f, \u865a\u8840\u5f8c\u306eTDP-43\u306e\u9650\u5b9a\u5206\u89e3\u3092\u6291\u5236\u3057 (P \u003c0.01), \u7d30\u80de\u8cea\u306b\u304a\u3051\u308b\u767a\u73fe\u3092\u6291\u5236\u3057\u305f. \u4ee5\u4e0a\u3088\u308a, TDP-43\u306f\u865a\u8840\u5f8c\u306b caspase-3\u4f9d\u5b58\u6027\u306b\u9650\u5b9a\u5206\u89e3\u3092\u53d7\u3051, \u7d30\u80de\u5185\u5c40\u5728\u3082\u5909\u5316\u3059\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f. \u3057\u304b\u3057, \u5909\u6027\u75be\u60a3\u3067\u898b\u3089\u308c\u308b\u3088\u3046\u306a\u30ea\u30f3\u9178\u5316\u3084\u4e0d\u6eb6\u5316\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f. \u865a\u8840\u306b\u4f34\u3044TDP-43\u306e\u9650\u5b9a\u5206\u89e3\u3084\u5c40\u5728\u5909\u5316\u306b\u3088\u308b\u6a5f\u80fd\u55aa\u5931\u304c\u751f\u3058\u305f\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u304c, TDP-43\u306e\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3051\u308b\u6a5f\u80fd\u306e\u89e3\u660e\u304c\u4eca\u5f8c\u91cd\u8981\u3067\u3042\u308b.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "72214", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kanazawa, Masato"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u91d1\u6fa4, \u96c5\u4eba"}], "nameIdentifiers": [{"nameIdentifier": "72213", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "123(11)_552-562.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "123(11)_552-562.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10556/files/123(11)_552-562.pdf"}, "version_id": "2e1e9f44-f3b7-4441-a418-673d2ca9f35b"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "TDP-43", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8133\u865a\u8840", "subitem_subject_scheme": "Other"}, {"subitem_subject": "caspase-3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30e9\u30c3\u30c8\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b caspase-3\u4f9d\u5b58\u6027 TARDNA\u7d50\u5408\u86cb\u767d-43\u306e\u9650\u5b9a\u5206\u89e3", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30e9\u30c3\u30c8\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b caspase-3\u4f9d\u5b58\u6027 TARDNA\u7d50\u5408\u86cb\u767d-43\u306e\u9650\u5b9a\u5206\u89e3"}, {"subitem_title": "\u30e9\u30c3\u30c8\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b caspase-3\u4f9d\u5b58\u6027 TARDNA\u7d50\u5408\u86cb\u767d-43\u306e\u9650\u5b9a\u5206\u89e3", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/973"], "permalink_uri": "http://hdl.handle.net/10191/28562", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-07-22"}, "publish_date": "2014-07-22", "publish_status": "0", "recid": "10556", "relation": {}, "relation_version_is_last": true, "title": ["\u30e9\u30c3\u30c8\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b caspase-3\u4f9d\u5b58\u6027 TARDNA\u7d50\u5408\u86cb\u767d-43\u306e\u9650\u5b9a\u5206\u89e3"], "weko_shared_id": null}