{"_buckets": {"deposit": "7de18421-3ebf-4985-9dc3-f9b126ea6106"}, "_deposit": {"id": "10208", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10208"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010208", "sets": ["456", "959"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Molecular Analysis of the Collagen Adhesin Gene in Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Bullous Impetigo"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "40", "bibliographicPageStart": "26", "bibliographicVolumeNumber": "125", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "メチシリン耐性黄色ブドウ球菌 (methicillin-resistant Staphylococcus aureus, MRSA) はその発見 (1961年) 以来院内感染の主要菌で, 院内感染型MRSA (hospital-acquired MRSA, HA-MRSA) とも呼ばれてきた. 一方, 1997-1999年以降, 市中で感染拡大する市中感染型MRSA (community-acquired MRSA, CA-MRSA) が出現, 世界の注目を集めた. 日本ではCA-MRSAは小児の伝染性膿痴疹 (水疱型膿痴疹 bullous impetigo) からも分離される. 本研究では伝染性膿痴疹から分離されたCA-MRSA (biCA-MRSA) の病原性状を解析した. 伝染性膿痴疹は黄色ブドウ球菌が産生する表皮剥脱毒素 (exfoliative toxin, ET) によって惹起される. しかし, biCA-MRSAの場合にはET陽性率は52.3%にすぎなかった. 一方, コラーゲン付着因子 (collagen adhesin, CNA) 陽性率は85.7%で, CNA陽性率がET陽性率より有意に高率であった (P =0.043). CNA遺伝子構造を決定した結果, 各ドメイン領域は高度に保存されていたが, B領域 (幹ドメイン) の繰り返し数はbiCA-MRSAのST型によって異なり, 分離頻度が一番高いST89型で3回と最も多かった. biCA-MRSAの場合, CNA (特にB領域の繰り返し数) が感染に強く関連していることが示唆された.", "subitem_description_type": "Abstract"}, {"subitem_description": "Methicillin-resistant Staphylococcus aureus (MRSA) has played a principal role in hospital infection since it was detected in 1961. It is termed hospital-acquired MRSA (HA-MRSA). On the other hand, community-acquired MRSA (CA-MRSA) appeared after 1997 to 1999, and has been internationally investigated. In Japan, CA-MRSA is also isolated from children with contagious impetigo (bullous impetigo). In this study, we analyzed CA-MRSA (biCA-MRSA) strains isolated from children with bullous impetigo. Of these strains, 52.3 and 85.7% were positive for exfoliative toxin (ET) and collagen adhesion factor (CNA), respectively, showing a significant difference (P =0.043). When determining the CAN gene structure, each domain region was favorably maintained. However, the number of B-region (stem-domain) repetitions depended on the ST type of biCA-MRSA. ST89 type strains, which were most commonly isolated, showed the largest number (3 times). The results suggest that CNA (especially the number of B-region repetitions) is closely involved infection with biCA-MRSA.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "70239", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shi, Da"}]}, {"nameIdentifiers": [{"nameIdentifier": "70240", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Higuchi, Wataru"}]}, {"nameIdentifiers": [{"nameIdentifier": "70241", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Saito, Kohei"}]}, {"nameIdentifiers": [{"nameIdentifier": "70242", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takano, Tomomi"}]}, {"nameIdentifiers": [{"nameIdentifier": "70243", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yamamoto, Tatsuo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "史, 達"}], "nameIdentifiers": [{"nameIdentifier": "70234", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口, 渉"}], "nameIdentifiers": [{"nameIdentifier": "70235", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "斎藤, 幸平"}], "nameIdentifiers": [{"nameIdentifier": "70236", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高野, 智洋"}], "nameIdentifiers": [{"nameIdentifier": "70237", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山本, 達男"}], "nameIdentifiers": [{"nameIdentifier": "70238", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "125(1)_26-40.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "125(1)_26-40.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/10208/files/125(1)_26-40.pdf"}, "version_id": "2ffc52e9-1aeb-4254-adfa-961c9ec71a07"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "伝染性膿痴疹", "subitem_subject_scheme": "Other"}, {"subitem_subject": "市中感染型メチシリン耐性黄色ブドウ球菌 (CA-MRSA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "表皮剥脱毒素 (ET)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "コラーゲン付着因子 (CNA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "遺伝子構造", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bullous impetigo", "subitem_subject_scheme": "Other"}, {"subitem_subject": "community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "exfoliative toxin (ET)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "collagen adhesion (CNA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gene structure", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析"}, {"subitem_title": "伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "959"], "permalink_uri": "http://hdl.handle.net/10191/28938", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-09-10"}, "publish_date": "2018-09-10", "publish_status": "0", "recid": "10208", "relation": {}, "relation_version_is_last": true, "title": ["伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析"], "weko_shared_id": null}