{"created":"2021-03-01T06:14:19.957494+00:00","id":10208,"links":{},"metadata":{"_buckets":{"deposit":"7de18421-3ebf-4985-9dc3-f9b126ea6106"},"_deposit":{"id":"10208","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10208"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010208","sets":["453:456","471:537:538:959"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Molecular Analysis of the Collagen Adhesin Gene in Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated from Bullous Impetigo"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"40","bibliographicPageStart":"26","bibliographicVolumeNumber":"125","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"メチシリン耐性黄色ブドウ球菌 (methicillin-resistant Staphylococcus aureus, MRSA) はその発見 (1961年) 以来院内感染の主要菌で, 院内感染型MRSA (hospital-acquired MRSA, HA-MRSA) とも呼ばれてきた. 一方, 1997-1999年以降, 市中で感染拡大する市中感染型MRSA (community-acquired MRSA, CA-MRSA) が出現, 世界の注目を集めた. 日本ではCA-MRSAは小児の伝染性膿痴疹 (水疱型膿痴疹 bullous impetigo) からも分離される. 本研究では伝染性膿痴疹から分離されたCA-MRSA (biCA-MRSA) の病原性状を解析した. 伝染性膿痴疹は黄色ブドウ球菌が産生する表皮剥脱毒素 (exfoliative toxin, ET) によって惹起される. しかし, biCA-MRSAの場合にはET陽性率は52.3%にすぎなかった. 一方, コラーゲン付着因子 (collagen adhesin, CNA) 陽性率は85.7%で, CNA陽性率がET陽性率より有意に高率であった (P =0.043). CNA遺伝子構造を決定した結果, 各ドメイン領域は高度に保存されていたが, B領域 (幹ドメイン) の繰り返し数はbiCA-MRSAのST型によって異なり, 分離頻度が一番高いST89型で3回と最も多かった. biCA-MRSAの場合, CNA (特にB領域の繰り返し数) が感染に強く関連していることが示唆された.","subitem_description_type":"Abstract"},{"subitem_description":"Methicillin-resistant Staphylococcus aureus (MRSA) has played a principal role in hospital infection since it was detected in 1961. It is termed hospital-acquired MRSA (HA-MRSA). On the other hand, community-acquired MRSA (CA-MRSA) appeared after 1997 to 1999, and has been internationally investigated. In Japan, CA-MRSA is also isolated from children with contagious impetigo (bullous impetigo). In this study, we analyzed CA-MRSA (biCA-MRSA) strains isolated from children with bullous impetigo. Of these strains, 52.3 and 85.7% were positive for exfoliative toxin (ET) and collagen adhesion factor (CNA), respectively, showing a significant difference (P =0.043). When determining the CAN gene structure, each domain region was favorably maintained. However, the number of B-region (stem-domain) repetitions depended on the ST type of biCA-MRSA. ST89 type strains, which were most commonly isolated, showed the largest number (3 times). The results suggest that CNA (especially the number of B-region repetitions) is closely involved infection with biCA-MRSA.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"70239","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shi, Da"}]},{"nameIdentifiers":[{"nameIdentifier":"70240","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Higuchi, Wataru"}]},{"nameIdentifiers":[{"nameIdentifier":"70241","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Saito, Kohei"}]},{"nameIdentifiers":[{"nameIdentifier":"70242","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takano, Tomomi"}]},{"nameIdentifiers":[{"nameIdentifier":"70243","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamamoto, Tatsuo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"史, 達"}],"nameIdentifiers":[{"nameIdentifier":"70234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 渉"}],"nameIdentifiers":[{"nameIdentifier":"70235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"斎藤, 幸平"}],"nameIdentifiers":[{"nameIdentifier":"70236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 智洋"}],"nameIdentifiers":[{"nameIdentifier":"70237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 達男"}],"nameIdentifiers":[{"nameIdentifier":"70238","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"125(1)_26-40.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"125(1)_26-40.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10208/files/125(1)_26-40.pdf"},"version_id":"2ffc52e9-1aeb-4254-adfa-961c9ec71a07"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"伝染性膿痴疹","subitem_subject_scheme":"Other"},{"subitem_subject":"市中感染型メチシリン耐性黄色ブドウ球菌 (CA-MRSA)","subitem_subject_scheme":"Other"},{"subitem_subject":"表皮剥脱毒素 (ET)","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲン付着因子 (CNA)","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子構造","subitem_subject_scheme":"Other"},{"subitem_subject":"Bullous impetigo","subitem_subject_scheme":"Other"},{"subitem_subject":"community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA)","subitem_subject_scheme":"Other"},{"subitem_subject":"exfoliative toxin (ET)","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen adhesion (CNA)","subitem_subject_scheme":"Other"},{"subitem_subject":"gene structure","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析"},{"subitem_title":"伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","959"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-09-10"},"publish_date":"2018-09-10","publish_status":"0","recid":"10208","relation_version_is_last":true,"title":["伝染性膿痂疹由来メチシリン耐性黄色ブドウ球菌 (MRSA)がもつコラーゲン付着因子に関する遺伝学的解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:00.322547+00:00"}