WEKO3
アイテム
{"_buckets": {"deposit": "9118b13c-bdd1-4ada-8f86-0b4bf1215a25"}, "_deposit": {"id": "6548", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6548"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006548", "sets": ["456", "634"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "156", "bibliographicPageStart": "151", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A trial administration of OK-432 by transarterial embolization (TAE) and intra-operative local injection (OLI) was performed to treat the liver metastasis of gastric cancer. The liver metastases decreased in size as assessed by abdominal CT scan. The peripheral level of DR^+ CD3^- monocytes (antigen-presenting cell) were increased on the day following OK-432 administration, and the increase in CD4^+ T lymphocytes (helper T cell) was prominent from 3 to 5 days afterward. Furthermore, the CD8^+ T lymphocyte (cytotxic T cell) level increased from 5 to 7 days after OK-432 treatment. The increase in the number of these lymphocytes after OLI with OK-432 was more prominent than that after TAE with OK--432. The concentration of DR^+CD4^+ T lymphocytes changed little, however, DR^+CD8^+ T lymphocytes increasing remarkably after TAE and OLI. NK activities decreased significantly on the day following TAE and abdominal operation, but increased afterward to at least pretreatment levels. On two-color flow cytometry using LEU 7 and LEU 11, which recognize NK surface antigens, each subpopulation of NK cells showed similar changes. However, LEU 11-positive cells comprised the majority of the NK cells. The kinetics of the NK subpopulation did not always correspond to that of NK activity, which may be due to the participation of neutrophils induced\\nby the liver biopsy. These results suggest that the local administration of OK-432 by TAE and OLI activates cell mediated immunity by stimulating antigen-presenting cells and helper and cytotoxic T cells, and may therefore be used to treat liver metastasis.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sato, Yoshinobu"}], "nameIdentifiers": [{"nameIdentifier": "53439", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "53440", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "40(4)_151-156.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "40(4)_151-156.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6548/files/40(4)_151-156.pdf"}, "version_id": "7e96c358-8215-4d44-9db9-9efa5e27a5c5"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis"}, {"subitem_title": "Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "634"], "permalink_uri": "http://hdl.handle.net/10191/33392", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-09-18"}, "publish_date": "2015-09-18", "publish_status": "0", "recid": "6548", "relation": {}, "relation_version_is_last": true, "title": ["Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis"], "weko_shared_id": null}
Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis
http://hdl.handle.net/10191/33392
http://hdl.handle.net/10191/3339243c7a7a2-c4ba-4ab8-9c42-c721808c66c9
名前 / ファイル | ライセンス | アクション |
---|---|---|
40(4)_151-156.pdf (1.0 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-09-18 | |||||
タイトル | ||||||
タイトル | Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Sato, Yoshinobu
× Sato, Yoshinobu× Fukuda, Minoru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A trial administration of OK-432 by transarterial embolization (TAE) and intra-operative local injection (OLI) was performed to treat the liver metastasis of gastric cancer. The liver metastases decreased in size as assessed by abdominal CT scan. The peripheral level of DR^+ CD3^- monocytes (antigen-presenting cell) were increased on the day following OK-432 administration, and the increase in CD4^+ T lymphocytes (helper T cell) was prominent from 3 to 5 days afterward. Furthermore, the CD8^+ T lymphocyte (cytotxic T cell) level increased from 5 to 7 days after OK-432 treatment. The increase in the number of these lymphocytes after OLI with OK-432 was more prominent than that after TAE with OK--432. The concentration of DR^+CD4^+ T lymphocytes changed little, however, DR^+CD8^+ T lymphocytes increasing remarkably after TAE and OLI. NK activities decreased significantly on the day following TAE and abdominal operation, but increased afterward to at least pretreatment levels. On two-color flow cytometry using LEU 7 and LEU 11, which recognize NK surface antigens, each subpopulation of NK cells showed similar changes. However, LEU 11-positive cells comprised the majority of the NK cells. The kinetics of the NK subpopulation did not always correspond to that of NK activity, which may be due to the participation of neutrophils induced\nby the liver biopsy. These results suggest that the local administration of OK-432 by TAE and OLI activates cell mediated immunity by stimulating antigen-presenting cells and helper and cytotoxic T cells, and may therefore be used to treat liver metastasis. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 40, 号 4, p. 151-156, 発行日 1992-12 |
|||||
出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |