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The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma
http://hdl.handle.net/10191/1956
http://hdl.handle.net/10191/1956840cbece-e313-4dc9-854b-caf6d817bcde
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004161687.pdf (2.6 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma | |||||
| タイトル | ||||||
| タイトル | The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | serrated adenoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-catenin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tumorigenesis of colorectal adenoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunohistochemistry | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Baba, Youichiro
× Baba, Youichiro× Ajioka, Yoichi× Hirono, Haruka× Watanabe, Gen× Nishikura, Ken× Watanabe, Hidenobu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The nuclear accumulation of β-catenin due to adenomatous polyposis coli (APC) gene alterations plays a central role in the tumorigenesis of the traditional tubular adenoma (TA) through activation of the Wingless/Wnt signal transduction pathway. To determine whether β-catenin plays a role in the tumorigenesis of the serrated adenoma (SA), a newly proposed subtype of colorectal adenoma, we immunohistochemically evaluated the nuclear expression of β-catenin in SA compared with that of the traditional TA. Twenty-three samples of SA without familial adenomatous polyposis (FAP) and 24 samples of TA without FAP and TA with FAP were respectively examined. While nuclear β-catenin expression was demonstrated in 79% (19/24) of TAs without FAP and 91% (22/24) of TAs with FAP, that in SAs was 0% (0/23). The difference in the expression rate in TAs without and with FAP from that in SAs was significant (p<0.0001, respectively). These results indicate that the tumorigenesis of the SA is distinct from that of the traditional TA and that the SA does not follow a APC/β-catenin/ Wnt signaling pathway. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 4, p. 127-132, 発行日 2004-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
