{"_buckets": {"deposit": "4b4e4cc6-1dc6-403a-a239-bd9db11664c0"}, "_deposit": {"id": "9862", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9862"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009862"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "New Strategy for Anti-hypertensive Treatment for Diabetic Patients (Rapid Progress of Diagnosis and Treatment in Diabetes Mellitus)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "662", "bibliographicPageStart": "659", "bibliographicVolumeNumber": "125", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Hypertension and diabetes mellitus are closely associated diseases which are both strongly related to the risk of cardiovascular disease. Major guidelines suggested that the goal blood pressure in patients with diabetes mellitus is less than 130/80 mmHg. An ACE inhibitor or Angiotensin II receptor blocker (ARB) is clearly preferred as initial therapy in any hypertensive diabetic patient in an attempt to slow renal disease progression. Monotherapy can attain goal blood pressure in some patients with diabetes and hypertension. This is most likely to occur in those with blood pressures that are only modestly above goal. However, combination therapy is eventually required in most patients. There is still some controversy about whether calcium channel blocker or low-dose hydrochlorothiazide provide better protection against cardiovascular events when both are used in combination with an ACE inhibitor or ARB. Other antihypertensive drugs can be added if the blood pressure goal is still not achieved. Aliskiren is the first member of the new class of orally active direct renin inhibitors which may also be a promising renoprotective strategy in patients with concomitant hypertension and diabetes mellitus.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u9ad8\u8840\u5727\u3068\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u30b4\u30fc\u30eb\u306f\u3068\u3082\u306b\u5fc3\u8840\u7ba1\u75c5 (Cardiovascular disease, CVD) \u306e\u56de\u907f\u3068\u6291\u5236\u3067\u3042\u308b. \u3068\u3082\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u75c5\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u591a\u304f, \u4e92\u3044\u306b\u4f75\u5b58\u3059\u308b\u7387\u3082\u9ad8\u3044. \u7cd6\u5c3f\u75c5\u306b\u4f34\u3046CVD\u306f\u91cd\u7be4\u30fb\u96e3\u6cbb\u3067\u3042\u308b\u305f\u3081, \u4e00\u6b21\u4e88\u9632\u304c\u91cd\u8981\u3067\u3042\u308b. \u5927\u898f\u6a21\u75ab\u5b66\u7814\u7a76\u306e\u7d50\u679c\u306b\u3088\u308a\u8840\u5727\u7ba1\u7406\u76ee\u6a19\u306f, \u9ad8\u8840\u5727\u5358\u72ec\u3088\u308a\u3082\u53b3\u683c\u3068\u306a\u3063\u3066\u304a\u308a, \u65e5\u672c\u9ad8\u8840\u5727\u5b66\u4f1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3042\u308bJSH2009 \u3067\u306f\u76ee\u6a19\u8840\u5727\u306f130/80mmHg\u3067\u3042\u308b. \u7cd6\u5c3f\u75c5\u5408\u4f75\u9ad8\u8840\u5727\u3067\u306e\u964d\u5727\u85ac\u306e\u7b2c\u4e00\u9078\u629e\u306f\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d20 (ACE) \u963b\u5bb3\u85ac\u307e\u305f\u306f\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3II\u53d7\u5bb9\u4f53\u30d6\u30ed\u30c3\u30ab\u30fc (ARB) \u3067\u3042\u308b. \u6cbb\u7642\u62b5\u6297\u4f8b\u3082\u591a\u304f, \u53b3\u683c\u306a\u964d\u5727\u76ee\u6a19\u9054\u6210\u306b\u306f\u591a\u5264\u4f75\u7528\u304c\u73fe\u5b9f\u7684\u3067\u3042\u308b. \u305d\u306e\u969b\u306e\u7b2c\u4e8c\u9078\u629e\u85ac\u3068\u3057\u3066\u30ab\u30eb\u30b7\u30a6\u30e0\u62ee\u6297\u85ac\u304b\u5229\u5c3f\u85ac\u306e\u3069\u3061\u3089\u304c\u6709\u7528\u304b\u306f\u7814\u7a76\u9014\u4e0a\u3067\u3042\u308b. \u6700\u8fd1\u306b\u306a\u3063\u3066\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3 (RAS) \u7cfb\u963b\u5bb3\u85ac\u306b\u65b0\u3057\u3044\u4f5c\u7528\u6a5f\u5e8f\u306e\u76f4\u63a5\u7684\u30ec\u30cb\u30f3\u963b\u5bb3\u85ac\u304c\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a, \u4eca\u5f8c\u305d\u306e\u6709\u7528\u6027\u304c\u691c\u8a0e\u3055\u308c\u3088\u3046.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "68103", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takeda, Tetsuro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7af9\u7530, \u5fb9\u6717"}], "nameIdentifiers": [{"nameIdentifier": "68102", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "125(12)_659-662.pdf", "filesize": [{"value": "675.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 675600.0, "url": {"label": "125(12)_659-662.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/9862/files/125(12)_659-662.pdf"}, "version_id": "d8227f6b-407f-4ed2-95c4-414fcf18405e"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Renin-Angiotensin-Aldosterone System \u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u30fb\u30a2\u30eb\u30c9\u30b9\u30c6\u30ed\u30f3\u30b7\u30b9\u30c6\u30e0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Direct Renin Inhibitor \u76f4\u63a5\u7684\u30ec\u30cb\u30f3\u963b\u5bb3\u85ac", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Selective Aldosterone Blocker", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Target blood pressure \u964d\u5727\u6a19\u5024", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "4 \u65b0\u3057\u3044\u964d\u5727\u85ac\u306e\u4f7f\u3044\u65b9(\u7cd6\u5c3f\u75c5\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u6025\u901f\u306a\u5c55\u958b,\u7b2c661\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "4 \u65b0\u3057\u3044\u964d\u5727\u85ac\u306e\u4f7f\u3044\u65b9(\u7cd6\u5c3f\u75c5\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u6025\u901f\u306a\u5c55\u958b,\u7b2c661\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "4 \u65b0\u3057\u3044\u964d\u5727\u85ac\u306e\u4f7f\u3044\u65b9(\u7cd6\u5c3f\u75c5\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u6025\u901f\u306a\u5c55\u958b,\u7b2c661\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/948"], "permalink_uri": "http://hdl.handle.net/10191/29321", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-07-29"}, "publish_date": "2014-07-29", "publish_status": "0", "recid": "9862", "relation": {}, "relation_version_is_last": true, "title": ["4 \u65b0\u3057\u3044\u964d\u5727\u85ac\u306e\u4f7f\u3044\u65b9(\u7cd6\u5c3f\u75c5\u306e\u8a3a\u65ad\u3068\u6cbb\u7642\u306e\u6025\u901f\u306a\u5c55\u958b,\u7b2c661\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}