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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第126巻第11号

5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会)

http://hdl.handle.net/10191/35434
http://hdl.handle.net/10191/35434
9ad5aaf2-5e33-46ca-9180-bc5dc90de5f6
名前 / ファイル ライセンス アクション
126(11)_589-592.pdf 126(11)_589-592.pdf (620.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-12-11
タイトル
タイトル 5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会)
タイトル
言語 en
タイトル 5 動脈硬化の基礎研究と治療への応用(シンポジウム 高血圧治療のUp-to-date, 第666回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 Hypertension
キーワード
主題Scheme Other
主題 atherosclerosis
キーワード
主題Scheme Other
主題 chronic kidney disease
キーワード
主題Scheme Other
主題 angiotensin II receptor antagonist
キーワード
主題Scheme Other
主題 peroxisome proliferator activated receptor γ agonist
キーワード
主題Scheme Other
主題 macrophage
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Mechanisms and Therapeutic Options for Atherosclerosis
著者 山本, 卓

× 山本, 卓

WEKO 65803

山本, 卓

Search repository
丸山, 弘樹

× 丸山, 弘樹

WEKO 65804

丸山, 弘樹

Search repository
風間, 順一郎

× 風間, 順一郎

WEKO 65805

風間, 順一郎

Search repository
成田, 一衛

× 成田, 一衛

WEKO 65806

成田, 一衛

Search repository
著者別名
識別子 65807
識別子Scheme WEKO
姓名 Yamamoto, Suguru
著者別名
識別子 65808
識別子Scheme WEKO
姓名 Maruyama, Hiroki
著者別名
識別子 65809
識別子Scheme WEKO
姓名 Kazama, Junichiro
著者別名
識別子 65810
識別子Scheme WEKO
姓名 Narita, Ichiei
抄録
内容記述タイプ Abstract
内容記述 Cardiovascular disease is dramatically increased across the entire spectrum of patients with chronic kidney disease. Angiotensin II has a role in renal damage-induced acceleration of atherosclerosis with hypertension in apolipoprotein E deficient (apoe-/-) mice. Losartan, an AII receptor antagonist (ARB), reduces uninephrectomy (UNx)-induced acceleration of atherosclerosis in apoe-/- mice. Losartan also modurates macrophage chemotaxis, cholesterol efflux and inflammation in vitro. We examined if peroxisome proliferator activated receptor γ (PPAR γ) agonist benefits UNx-induced acceleration of atherosclerosis and the possibility of a synergistic interaction with ARB. UNx mice were treated with pioglitazone (a PPAR γ agonist), losartan (an ARB), or both. UNx significantly increased atherosclerosis in proximal aorta which was lessened by pioglitazon and losartan, but especially by the combination which was significantly less than pioglitazone or losartan alone. Assessment of the plaque lesions revealed significantly less necrotic plaque area in the lesion with pioglitazon and losartan treatment. Notably, the macrophage area of combination treatment with pioglitazon and losartan had lesser number of pro-inflammatory M1 phenotype and greater number of alternatively anti-inflammatory M2 phenotype. Those results suggest that ARB especially together with PPAR γ agonist modurates macrophage functions in renal-injury-induced acceleration of atherosclerotic lesion. Therapeutic interventions for hypertension should be considered to modulate progressive atherosclerosis, especially macrophage function.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 126, 号 11, p. 589-592, 発行日 2012-11
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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