{"_buckets": {"deposit": "99c0f76f-e5fb-49c8-86ac-c9fc815d93a1"}, "_deposit": {"id": "9510", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "9510"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00009510"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Fight Against Rare Lung Diseases : Multi-Center International Sirolimus Trial for Lymphoangioliomyomatosis"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "577", "bibliographicPageStart": "573", "bibliographicVolumeNumber": "126", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u30ea\u30f3\u30d1\u8108\u7ba1\u7b4b\u816b\u75c7(Lymphangioleiomyomatosis ; LAM)\u306f\u82e5\u5e74\u5973\u6027\u304c\u7f79\u308a, \u4e88\u5f8c\u4e0d\u826f\u306e\u96e3\u75c5\u3067\u3042\u308b. \u30e9\u30d1\u30de\u30a4\u30b7\u30f3\u6a19\u7684\u86cb\u767d\u8cea(mTOR)\u963b\u5bb3\u85ac\u306e\u30b7\u30ed\u30ea\u30e0\u30b9\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c, \u533b\u5e2b\u4e3b\u5c0e\u306e\u56fd\u969b\u7684\u306a\u591a\u65bd\u8a2d\u5171\u540c\u81e8\u5e8a\u8a66\u9a13(Multicenter International LAM Efficacy of Sirolimus Trial ; MILES\u8a66\u9a13)\u3067\u691c\u8a3c\u3055\u308c, 2011\u5e743\u670816\u65e5\u306eThe New England Journal of Medicine\u306b\u5831\u544a\u3055\u308c\u305f. \u751f\u547d\u79d1\u5b66\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3068\u7b2c\u4e8c\u5185\u79d1\u547c\u5438\u5668\u30b0\u30eb\u30fc\u30d7\u306f, \u539a\u751f\u52b4\u50cd\u79d1\u5b66\u7814\u7a76\u8cbb\u300c\u81e8\u5e8a\u8a66\u9a13\u63a8\u9032\u7814\u7a76\u4e8b\u696d\u300d\u8cbb\u3092\u5f97\u3066, \u8fd1\u757f\u4e2d\u592e\u80f8\u90e8\u75be\u60a3\u30bb\u30f3\u30bf\u30fc\u3068\u3068\u3082\u306b\u540c\u8a66\u9a13\u306b\u53c2\u52a0\u3057, \u8a66\u9a13\u306e\u6210\u529f\u306b\u8ca2\u732e\u3057\u305f. \u53c2\u52a0\u307e\u3067\u306e\u7d4c\u7def\u3068\u7d50\u679c\u306b\u3064\u3044\u3066\u8ff0\u3079\u305f\u3044.", "subitem_description_type": "Abstract"}, {"subitem_description": "Lymphangioleiomyomatosis (LAM) is an uncommon lung disease that affects mostly female. LAM has an insidious onset, and is typically slowly progressive. Until recently, there was no proven therapies for LAM except for lung transplantation. To assess the effect of sirolimus, a mTOR inhibitor, on biological and clinical markers of lung function and to assess the safety, a trial was designed as a multi-center international, phase III, randomized, double-blind, placebo-controlled intention to treat (MILES trial). Respiratory disease group in The Second Department of Medicine and Bioscience Medical Research Center, Niigata University Hospital participated in the trial with Kinki Chuo Chest Medical Center and enrolled total 24 patients in Japan. On one year of oral sirolimus, patients with LAM and moderate respiratory impairment had significant but modest benefits on lung function and measures of quality of life or functional performance. The safety profile of the drug was acceptable and consistent with the known toxicities. Thus, Japanese research group contributed to the success of MILES trial.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "65796", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakata, Koh"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e2d\u7530, \u5149"}], "nameIdentifiers": [{"nameIdentifier": "65795", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "126(11)_573-577.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "126(11)_573-577.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/9510/files/126(11)_573-577.pdf"}, "version_id": "625d7f7a-b339-44a6-a40d-72121bc88108"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Lymphangioliomyomatosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "clinical trial", "subitem_subject_scheme": "Other"}, {"subitem_subject": "FEV1.0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "FVC", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7a00\u5c11\u80ba\u96e3\u75c5\u3068\u306e\u95d8\u3044 : \u30ea\u30f3\u30d1\u8108\u7ba1\u7b4b\u816b\u75c7\u306e\u56fd\u969b\u5171\u540c\u81e8\u5e8a\u8a66\u9a13", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7a00\u5c11\u80ba\u96e3\u75c5\u3068\u306e\u95d8\u3044 : \u30ea\u30f3\u30d1\u8108\u7ba1\u7b4b\u816b\u75c7\u306e\u56fd\u969b\u5171\u540c\u81e8\u5e8a\u8a66\u9a13"}, {"subitem_title": "\u7a00\u5c11\u80ba\u96e3\u75c5\u3068\u306e\u95d8\u3044 : \u30ea\u30f3\u30d1\u8108\u7ba1\u7b4b\u816b\u75c7\u306e\u56fd\u969b\u5171\u540c\u81e8\u5e8a\u8a66\u9a13", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/937"], "permalink_uri": "http://hdl.handle.net/10191/35435", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-12-11"}, "publish_date": "2015-12-11", "publish_status": "0", "recid": "9510", "relation": {}, "relation_version_is_last": true, "title": ["\u7a00\u5c11\u80ba\u96e3\u75c5\u3068\u306e\u95d8\u3044 : \u30ea\u30f3\u30d1\u8108\u7ba1\u7b4b\u816b\u75c7\u306e\u56fd\u969b\u5171\u540c\u81e8\u5e8a\u8a66\u9a13"], "weko_shared_id": null}