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腫瘍マーカーによる肝癌診断 ・治療戦略 AFP糖鎖変異を中心に（最終講義）
http://hdl.handle.net/10191/44015
http://hdl.handle.net/10191/44015bf0cd228-f1aa-4c8d-85eb-06583ecdd053
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
129(1)_1-9.pdf (691.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-27 | |||||
| タイトル | ||||||
| タイトル | 腫瘍マーカーによる肝癌診断 ・治療戦略 AFP糖鎖変異を中心に（最終講義） | |||||
| タイトル | ||||||
| タイトル | 腫瘍マーカーによる肝癌診断 ・治療戦略 AFP糖鎖変異を中心に（最終講義） | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アルファフェトプロテイン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | フコシル化 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 肝細胞癌 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | L3分画 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 多分岐化 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Altered Glycosylation of Alpha-fetoprotein in Patients with Hepatocellular Carcinoma, in Special Reference to Treatment to Hepatocellular Carcinoma | |||||
| 著者 |
青柳, 豊
× 青柳, 豊 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 61123 | |||||
| 姓名 | Aoyagi, Yutaka | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The quantitative determinations of AFP (alpha-fetoprotein) has been extensively used for the detection of HCC (hepatocellular carcinoma). However, the serum concentration of AFP also increases moderately in nonneoplastic liver diseases. Moreover, the serum concentrations of AFP in HCC at the time of initial diagnosis became lower recently owing to the advancement of imaging modalities. Accordingly, these clinical circumstances lead to molecular discrimination of AFP between HCC and benign liver diseases by taking advantage of the reactivity of AFP with various lectins. LCA-reactive species of AFP was significantly greater in HCC than benign liver diseases. Molecular basis of this variation is the fucosylation of sugar chain at innermost N-acetylglucosamine residue. On the other hand, Con A-nonreactive species of AFP was significantly higher in AFP-producing gastrointestinal carcinoma than HCC and benign liver diseases. Molecular basis of Con A-nonreactive variants is the N-acetylglucosaminylation of the mannose residue at the trimannosyl core although the position to be modified is different. Therefore, the terms "fucosylation index, that is L3 fraction and glucosaminylation indices" were adopted to express the percentages of LCA-reactive and Con A-nonreactive species of AFP, respectively. These indices are beneficial to the detection of HCC even if it is early stage. Furthermore, L3 from the sera before the initial treatment serves as a new prognostic factor and improves prognostic estimates and appraisal of therapeutic outcome in patients with HCC. Accordingly, not only quantitative but also qualitative measurements of AFP provide us very valuable information in the differential diagnosis of various liver diseases and the estimation of therapeutic outcome in patients with HCC. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 129, 号 1, p. 1-9, 発行日 2015-01 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
