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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第131巻第3号

心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節

http://hdl.handle.net/10191/47933
http://hdl.handle.net/10191/47933
4541e0ad-4b44-4b8c-a941-c64e757ef098
名前 / ファイル ライセンス アクション
131(3)_160-172.pdf 131(3)_160-172.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-09-22
タイトル
タイトル 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節
タイトル
言語 en
タイトル 心疾患におけるtitin, CaMKIIδおよびZASP/Cypher mRNAの選択的スプライシングの調節
言語
言語 jpn
キーワード
主題Scheme Other
主題 心筋炎
キーワード
主題Scheme Other
主題 心筋症
キーワード
主題Scheme Other
主題 心肥大
キーワード
主題Scheme Other
主題 選択的スプライシング
キーワード
主題Scheme Other
主題 低酸素
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Regulation of Alternative Splicing of Titin, CaMKIIδand ZASP/Cypher mRNAs in Heart Disease
著者 焦, 爽

× 焦, 爽

WEKO 58300

焦, 爽

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著者別名
識別子 58301
識別子Scheme WEKO
姓名 Jiao, Shuang
抄録
内容記述タイプ Abstract
内容記述 [Objectives] Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKII δ and ZASP/Cypher genes changes in hearts under pathological stress conditions. [Methods] The alternative splicing of titin, CaMKII δ and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients, monocrotaline pulmonary hypertension rats and in cardiomyocytes cultured under hypoxic conditions. [Results] Large N2BA-titin, cytoplasmic CaMKII δ and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and cytoplasmic CaMKII δ isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions, PGM1-binding ZASP/Cypher isoforms significantly increased, but large N2BA-titin and cytoplasmic CaMKII δ isoforms decreased, compared with cells under normoxic conditions. [Conclusions] The alternative splicing of titin, CaMKII δ and ZASP/Cypher genes was markedly modulated in hearts under pathological stress conditions and may be involved in adaptations to pathological changes.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 131, 号 3, p. 160-172, 発行日 2017-03
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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