{"_buckets": {"deposit": "0b36f618-75ca-41c3-abeb-3c1a6a927041"}, "_deposit": {"id": "8316", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8316"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008316"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Regulation of Alternative Splicing of Titin, CaMKII\u03b4and ZASP/Cypher mRNAs in Heart Disease"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "172", "bibliographicPageStart": "160", "bibliographicVolumeNumber": "131", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "[Objectives] Alternative splicing alters protein structure, localization and function and increases biological diversity in response to physiological and pathological stress conditions. We investigated how alternative splicing of titin, CaMKII \u03b4 and ZASP/Cypher genes changes in hearts under pathological stress conditions. [Methods] The alternative splicing of titin, CaMKII \u03b4 and ZASP/Cypher genes, in response to acute inflammation, pressure overload and hypoxia, was analyzed by quantitative RT-PCR in the hearts of experimental autoimmune myocarditis rats and myocarditis patients, monocrotaline pulmonary hypertension rats and in cardiomyocytes cultured under hypoxic conditions. [Results] Large N2BA-titin, cytoplasmic CaMKII \u03b4 and PGM1-binding ZASP/Cypher isoforms significantly increased in rat hearts with myocarditis and hypertrophy compared with normal hearts. Large N2BA-titin and cytoplasmic CaMKII \u03b4 isoforms also significantly increased in myocarditis patient hearts compared with those with DCM. In cardiomyocytes under hypoxic conditions, PGM1-binding ZASP/Cypher isoforms significantly increased, but large N2BA-titin and cytoplasmic CaMKII \u03b4 isoforms decreased, compared with cells under normoxic conditions. [Conclusions] The alternative splicing of titin, CaMKII \u03b4 and ZASP/Cypher genes was markedly modulated in hearts under pathological stress conditions and may be involved in adaptations to pathological changes.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "58301", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Jiao, Shuang"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7126, \u723d"}], "nameIdentifiers": [{"nameIdentifier": "58300", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "131(3)_160-172.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "131(3)_160-172.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/8316/files/131(3)_160-172.pdf"}, "version_id": "05dae3ff-81f3-41ab-9515-018757acbdd2"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u5fc3\u7b4b\u708e", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u7b4b\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5fc3\u80a5\u5927", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4f4e\u9178\u7d20", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u5fc3\u75be\u60a3\u306b\u304a\u3051\u308btitin, CaMKII\u03b4\u304a\u3088\u3073ZASP/Cypher mRNA\u306e\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8abf\u7bc0", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u5fc3\u75be\u60a3\u306b\u304a\u3051\u308btitin, CaMKII\u03b4\u304a\u3088\u3073ZASP/Cypher mRNA\u306e\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8abf\u7bc0"}, {"subitem_title": "\u5fc3\u75be\u60a3\u306b\u304a\u3051\u308btitin, CaMKII\u03b4\u304a\u3088\u3073ZASP/Cypher mRNA\u306e\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8abf\u7bc0", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/889"], "permalink_uri": "http://hdl.handle.net/10191/47933", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-09-22"}, "publish_date": "2017-09-22", "publish_status": "0", "recid": "8316", "relation": {}, "relation_version_is_last": true, "title": ["\u5fc3\u75be\u60a3\u306b\u304a\u3051\u308btitin, CaMKII\u03b4\u304a\u3088\u3073ZASP/Cypher mRNA\u306e\u9078\u629e\u7684\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u306e\u8abf\u7bc0"], "weko_shared_id": null}