{"_buckets": {"deposit": "34b65520-2b17-470e-ba35-d19d2dd8b07e"}, "_deposit": {"id": "6676", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6676"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006676"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1987-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "25", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "35", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Ultrastructural alterations of Ehrlich Ascites Tumor (EAT) cell nuclei following Mitomycin C (MC) treatment were investigated. The principal alterations in the nuclear ultrastructure were those of the chromatin and of the nucleolus. Unusual condensation or aggregation of chromatin was observed at 30 min as the initial change after MC administration. This pathologic condensation of chromatin developed to a maximum at 4 hr. Density of the nuclear matrix was gradually diminished thereafter to an extreme at 48-72 hr. The earliest morphologic alteration of the nucleolus was manifested at 4 hr after MC treatment as decreased density of the nucleolonema. Disintegration and decrease in density of the organelle became evident at 8-12 hr, and progressed to an extreme at 48-72 hr. Relationships between these ultrastructural alterations and the effects of MC on the nuclear metabolism, especially of DNA and of RNA, are discussed.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Suzuki, Tsutomu"}], "nameIdentifiers": [{"nameIdentifier": "53916", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "35(1)_1-25.pdf", "filesize": [{"value": "8.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 8199999.999999999, "url": {"label": "35(1)_1-25.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6676/files/35(1)_1-25.pdf"}, "version_id": "899c32a5-dbab-4539-bf9e-cbb302992b28"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment"}, {"subitem_title": "Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/656"], "permalink_uri": "http://hdl.handle.net/10191/33571", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-10-07"}, "publish_date": "2015-10-07", "publish_status": "0", "recid": "6676", "relation": {}, "relation_version_is_last": true, "title": ["Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment"], "weko_shared_id": null}