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Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment
http://hdl.handle.net/10191/33571
http://hdl.handle.net/10191/335719de0805e-79b8-4d4e-b0a0-917f7d9a4f18
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-07 | |||||
タイトル | ||||||
タイトル | Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Ultrastructural alterations of nuclei of Ehrlich Ascites Tumor cells after Mitomycin C treatment | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Suzuki, Tsutomu
× Suzuki, Tsutomu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ultrastructural alterations of Ehrlich Ascites Tumor (EAT) cell nuclei following Mitomycin C (MC) treatment were investigated. The principal alterations in the nuclear ultrastructure were those of the chromatin and of the nucleolus. Unusual condensation or aggregation of chromatin was observed at 30 min as the initial change after MC administration. This pathologic condensation of chromatin developed to a maximum at 4 hr. Density of the nuclear matrix was gradually diminished thereafter to an extreme at 48-72 hr. The earliest morphologic alteration of the nucleolus was manifested at 4 hr after MC treatment as decreased density of the nucleolonema. Disintegration and decrease in density of the organelle became evident at 8-12 hr, and progressed to an extreme at 48-72 hr. Relationships between these ultrastructural alterations and the effects of MC on the nuclear metabolism, especially of DNA and of RNA, are discussed. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 35, 号 1, p. 1-25, 発行日 1987-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |