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Oral ingestion of syloid to mice ande rats and its chronic toxicity and carcinogenicity
http://hdl.handle.net/10191/33551
http://hdl.handle.net/10191/33551dc22f0c9-dfaf-4ad2-b5b8-b98ca1f57083
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
36(1)_27-56.pdf (1.9 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-10-06 | |||||
| タイトル | ||||||
| タイトル | Oral ingestion of syloid to mice ande rats and its chronic toxicity and carcinogenicity | |||||
| タイトル | ||||||
| タイトル | Oral ingestion of syloid to mice ande rats and its chronic toxicity and carcinogenicity | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Takizawa, Yukio
× Takizawa, Yukio× Hirasawa, Fujiko× Noritomi, Emiko× Aida, Makiko× Tsunoda, Hiroshi× Uesugi, Shiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A long-term bioassay of chronic toxicity was conducted by orally administering the test material of food grade micronized silica, SYLOID (commercially produced by Fuji Davison Chemical Ltd., Japan), in a feed to B_6C_3F_1 mice and Fisher rats. The results of this study show that continuous dietary administration of SYLOID, at dose levels of 0, 1.25, 2.5, and 5%, to five-week-old specimens of both sexes for ca 93 consecutive weeks for mice and for ca 103 consecutive weeks for rats, causes no biological or any other meaningful alterations in body weight, food consumption, or physical features. No significant dose-related effects were seen at any dose level upon clinical laboratory examinations. Dietary administration of SYLOID to animals for the duration of a lifespan did not cause gross or microscopic changes in the tissues examined. The occasional presence of some neoplasms did not reveal any consistent, dose-related trends in any group. It may be concluded that proper dietary administration of micronized silica has proven to be generally safe with no long-term toxic effects. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 36, 号 1, p. 27-56, 発行日 1988-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
