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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.38 No.1

Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects

http://hdl.handle.net/10191/33472
http://hdl.handle.net/10191/33472
d699dd21-12de-4395-9c34-323275171a03
名前 / ファイル ライセンス アクション
38(1)_9-17.pdf 38(1)_9-17.pdf (1.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-01
タイトル
タイトル Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects
タイトル
タイトル Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Hattori, Akira

× Hattori, Akira

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Hattori, Akira

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Nagai, Tsuneo

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Nagai, Tsuneo

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Izumi, Tohru

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Izumi, Tohru

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Kojima, Tomoko

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Kojima, Tomoko

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Nagayama, Reizo

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Nagayama, Reizo

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Kimura, Michio

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Kimura, Michio

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Ojima, Kenji

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Ojima, Kenji

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Hanano, Masaharu

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Hanano, Masaharu

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Mito, Masao

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Mito, Masao

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Shibata, Akira

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Shibata, Akira

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抄録
内容記述タイプ Abstract
内容記述 Most results on platelet activation during exercise in normal subjects and patients have recently been criticized as artificial activation ex vivo. The present study examined the shape changes of circulating platelets together with some other parameters in healthy subjects during a bicycle ergometer exercise. Striking shape changes revealed were spherification (decrease in the discoidness index) and pseudopod formation (increase in population of platelets with pseudopods). These changes in platelet shape persisted for 30 min after the exercise and after haemodynamic parameters returned to the pre-exercise level. The changes in the discoidness index and pseudopod formation during the exercise were found to be identical with our previous findings on platelets activated in vitro by ADP or thrombin. Trapidil (600 mg daily for 2 weeks per os), a modulator of platelets activity and vascular functions, significantly suppressed the shape change, suggesting a possible clinical benefit.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 38, 号 1, p. 9-17, 発行日 1990-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
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Cite as

Hattori, Akira, Nagai, Tsuneo, Izumi, Tohru, Kojima, Tomoko, Nagayama, Reizo, Kimura, Michio, Ojima, Kenji, Hanano, Masaharu, Mito, Masao, Shibata, Akira, 1990, Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects: Niigata University School of Medicine, 9–17 p.

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