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Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects
http://hdl.handle.net/10191/33472
http://hdl.handle.net/10191/33472d699dd21-12de-4395-9c34-323275171a03
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
38(1)_9-17.pdf (1.5 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-10-01 | |||||
| タイトル | ||||||
| タイトル | Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects | |||||
| タイトル | ||||||
| タイトル | Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Hattori, Akira
× Hattori, Akira× Nagai, Tsuneo× Izumi, Tohru× Kojima, Tomoko× Nagayama, Reizo× Kimura, Michio× Ojima, Kenji× Hanano, Masaharu× Mito, Masao× Shibata, Akira |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Most results on platelet activation during exercise in normal subjects and patients have recently been criticized as artificial activation ex vivo. The present study examined the shape changes of circulating platelets together with some other parameters in healthy subjects during a bicycle ergometer exercise. Striking shape changes revealed were spherification (decrease in the discoidness index) and pseudopod formation (increase in population of platelets with pseudopods). These changes in platelet shape persisted for 30 min after the exercise and after haemodynamic parameters returned to the pre-exercise level. The changes in the discoidness index and pseudopod formation during the exercise were found to be identical with our previous findings on platelets activated in vitro by ADP or thrombin. Trapidil (600 mg daily for 2 weeks per os), a modulator of platelets activity and vascular functions, significantly suppressed the shape change, suggesting a possible clinical benefit. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38, 号 1, p. 9-17, 発行日 1990-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
