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Constriction of the Canine Coronary Artery Produced by Leukotriene D4 ; the Clinical Significance of Endogenous Leukotrienes, Neuropeptide Y, Angiotensin II, and Vasopressin
http://hdl.handle.net/10191/33490
http://hdl.handle.net/10191/334902973a426-d593-4c97-97db-73cffc47f0ac
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-01 | |||||
タイトル | ||||||
タイトル | Constriction of the Canine Coronary Artery Produced by Leukotriene D4 ; the Clinical Significance of Endogenous Leukotrienes, Neuropeptide Y, Angiotensin II, and Vasopressin | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Constriction of the Canine Coronary Artery Produced by Leukotriene D4 ; the Clinical Significance of Endogenous Leukotrienes, Neuropeptide Y, Angiotensin II, and Vasopressin | |||||
言語 | ||||||
言語 | eng | |||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Funazaki, Toshikazu
× Funazaki, Toshikazu× Aizawa, Yoshifusa× Murata, Minoru× Ebe, Katsuya× Tamura, Makoto× Yamaguchi, Toshio× Fuse, Ichiro× Shibata, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The coronary vasoconstrictive effects of leukotriene D_4 (LTD_4), neuropeptide Y (NPY), angiotensin II, and vasopressin were compared in anesthetized dogs. LTD_4 and NPY of the same molar dose (4.7 nmol) caused equipotent and sustained coronary vasoconstriction in a dose dependent manner. Angiotensin II and vasopressin also showed vasoconstrictor effects, though the dosages used in the experiments were beyond any physiologic range. On the other hand, human polymorphonuclear (PMN) leukocytes, stimulated maximally by arachidonic acids, produced 10-60 ng endogenous leukotriene C_4 (LTC_4) per 10^7 cells, which is also as potent a vasoconstrictor as LTD_4 and the precursor of LTD_4. We concluded that human PMN leukocytes could produce leukotrienes which were sufficient to cause coronary vasoconstriction. This vasoconstriction was seemed important mainly in pathologic situations when PMN leukocytes accumulate around the coronary arteries. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38, 号 4, p. 167-173, 発行日 1990-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |