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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.38(Supplement)

Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension

http://hdl.handle.net/10191/33500
http://hdl.handle.net/10191/33500
7424049f-dbc9-403e-9af5-86e2ac995c95
名前 / ファイル ライセンス アクション
38(Suppl.)_93-106.pdf 38(Suppl.)_93-106.pdf (4.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-10-01
タイトル
タイトル Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension
タイトル
タイトル Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Tanizawa, Takakuni

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Tanizawa, Takakuni

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Shimada, Kenji

× Shimada, Kenji

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Shimada, Kenji

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Tomimoto, Yasuhito

× Tomimoto, Yasuhito

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Tomimoto, Yasuhito

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Hattori, Masuji

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Hattori, Masuji

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Wada, Hiroyoshi

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Wada, Hiroyoshi

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Ikoma, Fumihiko

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Ikoma, Fumihiko

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Inaba, Susumu

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Inaba, Susumu

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Okada, Toshio

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Okada, Toshio

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Yanagihara, Toshio

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Yanagihara, Toshio

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Takada, Tsuneo

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Takada, Tsuneo

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内容記述タイプ Abstract
内容記述 We reported the clinicopathologic findings of 17 children with reflux nephropathy (RN) and the results of morphometric procedure for glomerular hypertrophy. The patients, including 13 boys and 4 girls, consisted of 8 with primary vesicoureteral reflux (VUR) and 9 with secondary VUR. Impaired renal function at renal biopsy (Ccr<50 ml/min/1.73 m^2) were observed in 12 patients. The latest renal status presents end-stage renal disease in 8 and progressive renal function deterioration in 4 patients. Although 4 patients showed end stage kidney, glomerular changes in 7 out of 13 patients showed focal glomerular sclerosis (focal and segmental-glomerular sclerosis: 3, focal and global obsolescence: 4) with moderate to severe tubulo-interstitial changes. Dysplastic lesion and Tamm-Horsfall glycoprotein in the dilatated tubular lumens or interstitial area were observed in 2 patients. A significant glomerular hypertrophy was evident in patients with diminished renal function and segmental/global glomerular sclerosis. These results suggest that nephron mass reduction due to renal scarring in RN leads to remnant glomerular overload, glomerular hyperperfusion or hypertension, and results in proteinuria and glomerular injury progressing to glomerular sclerosis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 38(Supplement), p. 93-106, 発行日 1990-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
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Cite as

Tanizawa, Takakuni, Shimada, Kenji, Tomimoto, Yasuhito, Hattori, Masuji, Wada, Hiroyoshi, Ikoma, Fumihiko, Inaba, Susumu, Okada, Toshio, Yanagihara, Toshio, Takada, Tsuneo, 1990, Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension: Niigata University School of Medicine, 93–106 p.

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