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Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension
http://hdl.handle.net/10191/33500
http://hdl.handle.net/10191/335007424049f-dbc9-403e-9af5-86e2ac995c95
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-10-01 | |||||
タイトル | ||||||
タイトル | Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension | |||||
タイトル | ||||||
タイトル | Reflux Nephropathy and Glomerular Sclerosis : Glomerular Hypertrophy as a Possible Result of Remnant Glomerular Hyperperfusion and Hypertension | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Tanizawa, Takakuni
× Tanizawa, Takakuni× Shimada, Kenji× Tomimoto, Yasuhito× Hattori, Masuji× Wada, Hiroyoshi× Ikoma, Fumihiko× Inaba, Susumu× Okada, Toshio× Yanagihara, Toshio× Takada, Tsuneo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We reported the clinicopathologic findings of 17 children with reflux nephropathy (RN) and the results of morphometric procedure for glomerular hypertrophy. The patients, including 13 boys and 4 girls, consisted of 8 with primary vesicoureteral reflux (VUR) and 9 with secondary VUR. Impaired renal function at renal biopsy (Ccr<50 ml/min/1.73 m^2) were observed in 12 patients. The latest renal status presents end-stage renal disease in 8 and progressive renal function deterioration in 4 patients. Although 4 patients showed end stage kidney, glomerular changes in 7 out of 13 patients showed focal glomerular sclerosis (focal and segmental-glomerular sclerosis: 3, focal and global obsolescence: 4) with moderate to severe tubulo-interstitial changes. Dysplastic lesion and Tamm-Horsfall glycoprotein in the dilatated tubular lumens or interstitial area were observed in 2 patients. A significant glomerular hypertrophy was evident in patients with diminished renal function and segmental/global glomerular sclerosis. These results suggest that nephron mass reduction due to renal scarring in RN leads to remnant glomerular overload, glomerular hyperperfusion or hypertension, and results in proteinuria and glomerular injury progressing to glomerular sclerosis. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 38(Supplement), p. 93-106, 発行日 1990-03 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |