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Aberrant Keratinization in Skin Neoplasms, with Production of Anti-keratin Monoclonal Antibody (Mo-1)
http://hdl.handle.net/10191/33442
http://hdl.handle.net/10191/334421211891c-b655-408d-97f6-246caf84351b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39(2)_91-99.pdf (3.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-28 | |||||
| タイトル | ||||||
| タイトル | Aberrant Keratinization in Skin Neoplasms, with Production of Anti-keratin Monoclonal Antibody (Mo-1) | |||||
| タイトル | ||||||
| タイトル | Aberrant Keratinization in Skin Neoplasms, with Production of Anti-keratin Monoclonal Antibody (Mo-1) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Fujiwara, Hiroshi
× Fujiwara, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Eighteen cases of squamous cell carcinoma (SCC) were examined to reveal its characteristics of differentiation, especially keratinization. Immunohistological procedures were performed with anti-keratin antibodies (Mo-1, K-92, and HKN-5), anti-involucrin, anti-CEA, and anti-epidermal growth factor receptor antibodies. Mo-1 is a monoclonal antibody, produced in the present study, and found to recognize the 58 kd keratin filament of the basal layer of the skin. The results were compared with those of basal cell epithelioma (BCE), Bowen's disease, and seborrheic keratosis. In keratinized foci of SCC, Bowen's disease, and seborrheic keratosis, a positive stain of differentiation-associated keratin and involucrin, a negative sign of Mo-1, and a gradually diminished sign of epidermal growth factor receptor were obtained. A membranous stain of CEA and an irregular, "mosaic" pattern of HKN-5 were observed in most of the SCC and BCE, occasionally in Bowen's disease, and rarely in seborrheic keratosis. Though their keratinized regions were morphologically similar, the expression of intra- and extra-cellular materials of the tumor differed among each other. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39, 号 2, p. 91-99, 発行日 1991-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
