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Criteria and Classification of Hybrid Acute Leukemia in 72 Acute Leukemias Based Mainly on Flow Cytometric Analysis
http://hdl.handle.net/10191/33451
http://hdl.handle.net/10191/33451bc65eda6-a51d-48bf-8441-2c3eb9550449
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39(4)_169-174.pdf (745.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-28 | |||||
| タイトル | ||||||
| タイトル | Criteria and Classification of Hybrid Acute Leukemia in 72 Acute Leukemias Based Mainly on Flow Cytometric Analysis | |||||
| タイトル | ||||||
| タイトル | Criteria and Classification of Hybrid Acute Leukemia in 72 Acute Leukemias Based Mainly on Flow Cytometric Analysis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Aoki, Sadao
× Aoki, Sadao× Nomoto, Nobuhiko× Maruyama, Souichi× Shinada, Shoji× Shibata, Akira |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Phenotypes of leukemic cells can be determined through dual staining with pairs of FITC-labeled and PE-labeled monoclonal antibodies using a laser flow cytometer. Hybrid acute leukemia (HAL) was diagnosed when leukemic cells expressed 2 or more lymphoid markers and at least on myeloid marker simultaneously. Based on this criteria, nineteen out of 72 cases with untreated acute leukemia were diagnosed as HAL, 15 of 29 (51%) patients with acute lymphoblastic leukemia and 4 of 43 (9%) patients with acute non-lymphocytic leukemia were diagnosed as having HAL. We classified these HAL cells into 4 types by the following items. Type I: leukemic cells expressing only CD33 and 2 or more B-cell antigens; Type II: only CD33 and 2 or more T-cell antigens; Type III: two myeloid antigens (CD13, CD33) and 2 or more B-cell antigens; and Type IV: at least 2 of 3 myeloid antigens (CD13, CD33), peroxidase) and 2 or more T-cell antigens. There were 7 Type I cases and 3 Type II cases. These two types were thought to be ALL accompanied with positive CD33 alone, which meant a weak specificity as a myeloid marker. There were 6 Type III cases and 3 Type IV cases. Types III and IV were regarded as definite HAL since they had both myeloid and lymphoid antigens distinctly. The incidence of definite HAL among 72 acute leukemias was 12.5%. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39, 号 4, p. 169-174, 発行日 1991-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
