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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40 No.1

The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol

http://hdl.handle.net/10191/33375
http://hdl.handle.net/10191/33375
b674f6b0-8b9d-458e-89ea-c3abf080a525
名前 / ファイル ライセンス アクション
40(1)_35-41.pdf 40(1)_35-41.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-18
タイトル
タイトル The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol
タイトル
タイトル The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Satoh, Masahito

× Satoh, Masahito

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Satoh, Masahito

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内容記述タイプ Abstract
内容記述 Isoproterenol has been used in electrophysiologic studies to facilitate the induction of ventricular tachycardia (VT) as well as in drug testing. However, the mechanism of the induction of VT and the clinical significance of the VT induced with isoproterenol have yet to be determined. The present study assessed the effects of isoproterenol in the induction of VT during drug testing in 23 patients (34 drug testings), and analyzed the patients' characteristics and electrophysiologic parameters. The standard protocol for inducing VT was used. Sustained monomorphic VT was induced in 15 testings after the use of isoproterenol (ineffective drug testing). In the other 19 testings, sustained VT was not induced even after the use of isoproterenol (effective drug testing). Isoproterenol altered the electrophysiologic parameters in a similar manner in the two testings. However, nonsustained VT was more frequently induced before isoproterenol in the ineffective drug testings: 60% vs 16% (P <0.05). This indicates that isoproterenol converted nonsustained VT into sustained VT, implying that isoproterenol improved the conduction within the slow conduction zone, resulting in VT which did not terminate spontaneously. Facilitated conduction outside the reentry circuit, namely, the interventing tissue between the stimulation site and the reentry circuit, likely played a minor role. The majority of patients treated with an effective drug showed no recurrence of VT during the follow-up period.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40, 号 1, p. 35-41, 発行日 1992-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
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Satoh, Masahito, 1992, The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol: Niigata University School of Medicine, 35–41 p.

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