{"_buckets": {"deposit": "9dad56c6-b6af-497f-a491-4a0466368c76"}, "_deposit": {"id": "6567", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6567"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006567"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "19", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "This study aims to determine the minimum doses of aspirin required to inhibit spontaneous platelet aggregation (SPA) in patients with thrombocytosis. In vitro effects of a thromboxane synthetase inhibitor (OKY-1581) and aspirin on SPA were examined. Aspirin in vitro inhibited SPA at 10^\u003c-4\u003e M whereas OKY-1581 did in wide range of 36\u00d710^\u003c-7\u003e -36\u00d710^\u003c-4\u003e M. In an in vivo assessment of aspirin, nine patients who showed SPA were tested for such as SPA, aggregation induced by ADP, collagen, arachidonate and malondialdehide production after daily administration of 10-60 mg of aspirin for at least one week. The aspirin inhibited SPA in a dose dependent manner. Although varing among patients, the minimum doses of aspirin, ranging from 10 to 60 mg, were far lower than the doses described thus far in the literature (500-1,000 mg), and changed during the observation period. For patients with thrombocytosis accompanying arterial insufficiency, the dosage of aspirin should be determined individually based on assessments regarding platelet aggregation.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nagayama, Reizo"}], "nameIdentifiers": [{"nameIdentifier": "53515", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "40(1)_11-19.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "40(1)_11-19.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6567/files/40(1)_11-19.pdf"}, "version_id": "3a2a4351-49ce-4794-a8fb-3d97c0e1f5b9"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro"}, {"subitem_title": "Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/637"], "permalink_uri": "http://hdl.handle.net/10191/33372", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-09-18"}, "publish_date": "2015-09-18", "publish_status": "0", "recid": "6567", "relation": {}, "relation_version_is_last": true, "title": ["Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro"], "weko_shared_id": null}