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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40 No.1

Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro

http://hdl.handle.net/10191/33372
http://hdl.handle.net/10191/33372
f110c2e1-a6e8-4b8f-ac69-6fcaad007cf9
名前 / ファイル ライセンス アクション
40(1)_11-19.pdf 40(1)_11-19.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-18
タイトル
タイトル Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro
タイトル
言語 en
タイトル Studies on Administration of Aspirin in Thrombocytosis : Individualization of Minimum Dose Administration and Effect of Thromboxane Synthetase Inhibitor on Spontaneous Platelet Aggregation in vitro
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Nagayama, Reizo

× Nagayama, Reizo

WEKO 53515

Nagayama, Reizo

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抄録
内容記述タイプ Abstract
内容記述 This study aims to determine the minimum doses of aspirin required to inhibit spontaneous platelet aggregation (SPA) in patients with thrombocytosis. In vitro effects of a thromboxane synthetase inhibitor (OKY-1581) and aspirin on SPA were examined. Aspirin in vitro inhibited SPA at 10^<-4> M whereas OKY-1581 did in wide range of 36×10^<-7> -36×10^<-4> M. In an in vivo assessment of aspirin, nine patients who showed SPA were tested for such as SPA, aggregation induced by ADP, collagen, arachidonate and malondialdehide production after daily administration of 10-60 mg of aspirin for at least one week. The aspirin inhibited SPA in a dose dependent manner. Although varing among patients, the minimum doses of aspirin, ranging from 10 to 60 mg, were far lower than the doses described thus far in the literature (500-1,000 mg), and changed during the observation period. For patients with thrombocytosis accompanying arterial insufficiency, the dosage of aspirin should be determined individually based on assessments regarding platelet aggregation.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40, 号 1, p. 11-19, 発行日 1992-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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