ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate

To

Field does not validate

To
lat lon distance


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40(Supplement)

Reflux Nephropathy : Role of Bacterial Antigens and Urinary Proteins

http://hdl.handle.net/10191/33415
http://hdl.handle.net/10191/33415
f695ca6c-1726-4071-ab3d-9b4e86251a47
名前 / ファイル ライセンス アクション
40(Suppl.)_31-47.pdf 40(Suppl.)_31-47.pdf (2.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-24
タイトル
タイトル Reflux Nephropathy : Role of Bacterial Antigens and Urinary Proteins
タイトル
タイトル Reflux Nephropathy : Role of Bacterial Antigens and Urinary Proteins
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Miyata, Hiroshi

× Miyata, Hiroshi

WEKO 53414

Miyata, Hiroshi

Search repository
Yamamoto, Takashi

× Yamamoto, Takashi

WEKO 53415

Yamamoto, Takashi

Search repository
Moriguchi, Naohiko

× Moriguchi, Naohiko

WEKO 53416

Moriguchi, Naohiko

Search repository
Kinoshita, Tomohiro

× Kinoshita, Tomohiro

WEKO 53417

Kinoshita, Tomohiro

Search repository
Fujiyama, Tadakiyo

× Fujiyama, Tadakiyo

WEKO 53418

Fujiyama, Tadakiyo

Search repository
Kataoka, Satoru

× Kataoka, Satoru

WEKO 53419

Kataoka, Satoru

Search repository
Kanazaki, Michiharu

× Kanazaki, Michiharu

WEKO 53420

Kanazaki, Michiharu

Search repository
Michibata, Iwao

× Michibata, Iwao

WEKO 53421

Michibata, Iwao

Search repository
Maki, Sunao

× Maki, Sunao

WEKO 53422

Maki, Sunao

Search repository
抄録
内容記述タイプ Abstract
内容記述 Monoclonal antibodies (MoAbs) were raised against pyelonephritis-associated P-pili (PAP-pili) and Tamm-Horsfall glycoprotein (THGP). These MoAbs were μ-, κ-chain specific and reacted with polypeptides of 18 kD (PAP-pili) or 90 kD (THGP). The epitope of the MoAb directed against PAP-pili was present at the apical portion of the pilus. MoAbs against THGP recognized 4 distinct epitopes, and one MoAb stained immunofluorescent material inside both Bowmann's capsule and renal tubular cells on frozen sections from a kidney without obstructive or interstitial changes. Analysis of E. coli phenotypes with MoAbs against PAP-pili and with polyvalent 0 and KI antisera showed that organisms positive for PAP-pili, 01, and KI antigens were the more common causes of acute pyelonephritis. The chemiluminescence response of polymorphonuclear leukocytes was prominent following stimulation with 0 or K antigens isolated form pyelonephritic or enteropathogenic E. coli strains. Pyelonephritopathogenic E. coli may thus be a small number of strains which stimulate an energetic leukocyte response that produces more severe renal lesions. Pyelonephritis patients had high urinary free light chain levels regardless of the presence of vesicoureteral reflux or recurrent infection. THGP bound nonspecifically to these light chains and to IgA. In patients with reflux nephropathy, heavy tubular excretion of such proteins and their binding to THGP may interfere with urine outflow. Recurrent infection by virulent organisms and interactions between THGP and other urinary proteins may thus aggravate reflux nephropathy.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40(Supplement), p. 31-47, 発行日 1992-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:35:55.900543
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3