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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40(Supplement)

Experimental Analysis of Bacterial and Host Factors Involved in Renal Scarring

http://hdl.handle.net/10191/33414
http://hdl.handle.net/10191/33414
8d5019dc-f85f-4188-ac07-49bb0878609b
名前 / ファイル ライセンス アクション
40(Suppl.)_23-29.pdf 40(Suppl.)_23-29.pdf (882.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-24
タイトル
タイトル Experimental Analysis of Bacterial and Host Factors Involved in Renal Scarring
タイトル
言語 en
タイトル Experimental Analysis of Bacterial and Host Factors Involved in Renal Scarring
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Matsumoto, Tetsuro

× Matsumoto, Tetsuro

WEKO 53406

Matsumoto, Tetsuro

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Haraoka, Masashi

× Haraoka, Masashi

WEKO 53407

Haraoka, Masashi

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Mizunoe, Yoshimitsu

× Mizunoe, Yoshimitsu

WEKO 53408

Mizunoe, Yoshimitsu

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Kubo, Shuta

× Kubo, Shuta

WEKO 53409

Kubo, Shuta

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Takahashi, Koichi

× Takahashi, Koichi

WEKO 53410

Takahashi, Koichi

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Tanaka, Masatoshi

× Tanaka, Masatoshi

WEKO 53411

Tanaka, Masatoshi

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Ogata, Nobuo

× Ogata, Nobuo

WEKO 53412

Ogata, Nobuo

Search repository
Kumazawa, Joichi

× Kumazawa, Joichi

WEKO 53413

Kumazawa, Joichi

Search repository
抄録
内容記述タイプ Abstract
内容記述 The effects on renal scarring of bacterial pili and superoxide released by polymorphonuclear leukocytes (PMN) were examined using a rat experimental pyelonephritis model. Bacteria which possessed mannose-sensitive (MS) pili were found to promote renal scarring following their direct inoculation into the renal parenchyma. Treatment with cyclophosphamide to induce leukopenia, colchicine to modulate PMN migration, and superoxide dismutase or an experimental antioxidant to reduce PMN superoxide release suppressed renal scarring following infection with MS-piliated bacteria. In contrast, treatment with phorbol myristate acetate significantly enhanced renal scarring. In addition, the production of superoxide by PMN was significantly greater following stimulation by MS-piliated bacteria than after stimulation with either non-piliated or MR-piliated strains. These findings suggest that MS-piliated bacteria stimulate renal scarring more markedly than do non-piliated or MR-piliated bacteria, and that superoxide released from PMNs plays an important role in the development of renal scarring following infection by MS-piliated strains.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40(Supplement), p. 23-29, 発行日 1992-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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