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Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides
http://hdl.handle.net/10191/33314
http://hdl.handle.net/10191/33314da57b97f-36aa-4545-9863-2d3dead888d0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41(1)_25-31.pdf (892.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-11 | |||||
| タイトル | ||||||
| タイトル | Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides | |||||
| タイトル | ||||||
| タイトル | Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Tajima, Yutaka
× Tajima, Yutaka× Tadano, Jutaro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the denaturing effects of deoxycholate and estrogen-3-monosulfate on antithrombin III (AT III) in vitro. These compounds reduced in parallel both the immunological and anticoagulant activity of AT III at high concentrations, and such denaturing effects were considered to be due to their detergent-like effect. These compounds made AT III heat-labile and reduced the affinity of AT III to sulfated polysaccharides such as heparin attached to agarose gel at lower concentrations, which showed no direct denaturation yet. These results indicate that such compounds bind to a lipophilic portion, which may be involved with the function of AT III. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 41, 号 1, p. 25-31, 発行日 1993-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
