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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.41 No.1

Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides

http://hdl.handle.net/10191/33314
da57b97f-36aa-4545-9863-2d3dead888d0
名前 / ファイル ライセンス アクション
41(1)_25-31.pdf 41(1)_25-31.pdf (892.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-11
タイトル
タイトル Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides
タイトル
言語 en
タイトル Steroid Derivatives Reduce the Activity of Antithrombin III and the Affinity to Sulfated Polysaccharides
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Tajima, Yutaka

× Tajima, Yutaka

WEKO 53390

Tajima, Yutaka

Search repository
Tadano, Jutaro

× Tadano, Jutaro

WEKO 53391

Tadano, Jutaro

Search repository
抄録
内容記述タイプ Abstract
内容記述 We examined the denaturing effects of deoxycholate and estrogen-3-monosulfate on antithrombin III (AT III) in vitro. These compounds reduced in parallel both the immunological and anticoagulant activity of AT III at high concentrations, and such denaturing effects were considered to be due to their detergent-like effect. These compounds made AT III heat-labile and reduced the affinity of AT III to sulfated polysaccharides such as heparin attached to agarose gel at lower concentrations, which showed no direct denaturation yet. These results indicate that such compounds bind to a lipophilic portion, which may be involved with the function of AT III.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 41, 号 1, p. 25-31, 発行日 1993-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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