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Immunohistochemical Detection of Pancreatic Secretory Trypsin Inhibitor (PSTI) in Urothelial Cancer
http://hdl.handle.net/10191/33322
http://hdl.handle.net/10191/33322c7696b73-fa5c-4e43-9179-da38e98f6380
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
41(2)_109-112.pdf (877.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-11 | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical Detection of Pancreatic Secretory Trypsin Inhibitor (PSTI) in Urothelial Cancer | |||||
| タイトル | ||||||
| タイトル | Immunohistochemical Detection of Pancreatic Secretory Trypsin Inhibitor (PSTI) in Urothelial Cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Kimura, Motohiko
× Kimura, Motohiko× Tomita, Yoshihiko× Nishiyama, Tsutomu× Sato, Shotaro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pancreatic secretory trypsin inhibitor (PSTI), a specific trypsin inhibitor secreted by acinar cells of pancreas, also acts as a growth factor. PSTI in various cancers has been reported to be associated with tumor invasiveness and pathological malignancy; however, such studies in urological cancers have not yet been performed. We therefore examined the expression of PSTI in fresh frozen specimens of urothelial cancers immunohistochemically, using a polyclonal antibody. In 59 tumors (30 urinary bladder cancers, 16 ureteral cancers, and 13 renal pelvic cancers), 28 (47%) showed positive staining. In 44 transitional cell carcinomas (TCC), immunopositive tumor cells were observed in 16 (36%). However, there were no obvious differences in the incidence of PSTI expression among stages and grades. In 12 tumors with squamous cell cancer (SCC) cells, 10 tumors (83%) showed intense positive staining in SCC cells. These results suggest that the degree of expression of PSTI might be used for prognostic purposes since the prognosis of urothelial SCC patients has been reported to be significantly poorer than that of TCC ones. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 41, 号 2, p. 109-112, 発行日 1993-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
