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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.41 No.2

Multiplicity of Sites for Extrathymic T-cell Differentiation

http://hdl.handle.net/10191/33317
http://hdl.handle.net/10191/33317
398422c5-6952-468c-b57b-c6f88f306314
名前 / ファイル ライセンス アクション
41(2)_59-79.pdf 41(2)_59-79.pdf (4.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-11
タイトル
タイトル Multiplicity of Sites for Extrathymic T-cell Differentiation
タイトル
言語 en
タイトル Multiplicity of Sites for Extrathymic T-cell Differentiation
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Abo, Toru

× Abo, Toru

WEKO 53341

Abo, Toru

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Watanabe, Hisami

× Watanabe, Hisami

WEKO 53342

Watanabe, Hisami

Search repository
Sekikawa, Hiroho

× Sekikawa, Hiroho

WEKO 53343

Sekikawa, Hiroho

Search repository
抄録
内容記述タイプ Abstract
内容記述 In addition to an intrathymic pathway of T-cell differentiation, extrathymic pathways of T-cell differentiation have been found to exist at multiple sites in the living bodies of both mice and humans. Such sites include the sinusoids in the liver, intraepithelial sites in the intestine, the splenic red pulp, the thymic medulla, the decidua in the uterus, and the omentum in the peritoneal cavity. Although extrathymic pathways are minimal in youth, they become predominant with aging and under conditions of bacterial infections, pregnancy, malignancies and autoimmune diseases. Since T cells with extrathymic properties are present even in the thymic medulla, and all of them carry many properties of primitive T cells irrespective the sites where they exist, their differentiation pathways should be termed "primitive pathways of T-cell differentiation" rather than extrathymic pathways. In this review, we introduce the phenotypic and functional properties of these primitive T cells and discuss why such primitive T cells exist at multiple sites.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 41, 号 2, p. 59-79, 発行日 1993-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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