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Drug Sensitivity of Small Cell Gastrointestinal Carcinoma
http://hdl.handle.net/10191/33231
http://hdl.handle.net/10191/33231665f8dca-f93c-416a-b5eb-cfd8b291ed76
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
42(1)_1-5.pdf (475.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-04 | |||||
| タイトル | ||||||
| タイトル | Drug Sensitivity of Small Cell Gastrointestinal Carcinoma | |||||
| タイトル | ||||||
| タイトル | Drug Sensitivity of Small Cell Gastrointestinal Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Fujiwara, Takato
× Fujiwara, Takato× Motoyama, Teiichi× Ishihara, Noriko× Watanabe, Hidenobu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Small cell gastrointestinal carcinoma frequently denotes a poor prognosis. In this study, we carried out drug sensitivity tests in vitro, using four small cell gastrointestinal carcinoma cell lines and seven different anti-cancer agents, and the results were compared with those obtained in small cell lung carcinoma (SCLC) and common gastric carcinoma cell lines. In addition to the SCLC lines, Lu-130 and LU-139, the ECC18 cell line was sensitive to mitomycin C (MMC) and vincristine (VCR), while the other three small cell gastrointestinal carcinoma cell lines, ECC10, ECC12 and ECC4, were not sensitive to these agents. Only ECC4 cells were sensitive to 5-fluorouracil (5-FU). Our previous study showed that the ECC18 cell line had similarities to the biochemical variant of SCLC cells, and the three other small cell gastrointestinal carcinoma cell lines were similar to the morphological variant of SCLC cells. The present findings suggest that a regimen including MMC and VCR should be selected as the first choice for treatment of the biological variant of small cell gastrointestinal carcinoma, while most anti-cancer drugs in use at the present time are not effective in the treatment of the morphological variant of small cell gastrointestinal carcinoma. Thus, the development of new anti-cancer agents seems necessary for the morphological variant of small cell gastrointestinal carcinoma. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 42, 号 1, p. 1-5, 発行日 1994-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
