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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.42 No.4

Insulin-like Growth Factor-I (IGF-I) in Malnourished Rats Following Major Hepatic Resection

http://hdl.handle.net/10191/33255
http://hdl.handle.net/10191/33255
6c012762-821e-4c7b-9b59-28d322430e1b
名前 / ファイル ライセンス アクション
42(4)_159-163.pdf 42(4)_159-163.pdf (646.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-04
タイトル
タイトル Insulin-like Growth Factor-I (IGF-I) in Malnourished Rats Following Major Hepatic Resection
タイトル
言語 en
タイトル Insulin-like Growth Factor-I (IGF-I) in Malnourished Rats Following Major Hepatic Resection
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Sato, Nobuaki

× Sato, Nobuaki

WEKO 53164

Sato, Nobuaki

Search repository
Koyama, Yu

× Koyama, Yu

WEKO 53165

Koyama, Yu

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Oyamatsu, Manabu

× Oyamatsu, Manabu

WEKO 53166

Oyamatsu, Manabu

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Kayama, Seiji

× Kayama, Seiji

WEKO 53167

Kayama, Seiji

Search repository
Yoshikawa, Keiji

× Yoshikawa, Keiji

WEKO 53168

Yoshikawa, Keiji

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Ohkawa, Akira

× Ohkawa, Akira

WEKO 53169

Ohkawa, Akira

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Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 53170

Hatakeyama, Katsuyoshi

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Muto, Terukazu

× Muto, Terukazu

WEKO 53171

Muto, Terukazu

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抄録
内容記述タイプ Abstract
内容記述 We examined the effect of malnutrition on liver regeneration and changes in plasma insulin-like growth factor-I (IGF-I) concentrations, and the effect of the administration of IGF-I to rats following hepatic resection. Twenty-nine male Spraugue-Dawley rats were allocated to one of three groups. Group I (n = 11) consisted of normally nourished rats which each underwent a 70% partial hepatectomy by the method of Higgins and Anderson. Group II (n = 8) was composed of malnourished rats which also underwent partial hepatectomies. Group III (n=10) consisted of malnourished rats which each underwent a partial hepatectomy and received 200 μg of exogenous IGF-I for 24h following surgery. Group I rats were permitted to eat ad libitum., rats in Groups II and III received 50% of their normal intake for one week prior to and following hepatectomy. The rats were killed after 48 h of hepatic regeneration, and the livers were weighed and prepared for hamatoxylineosin staining to facilitate an assessment of the number of mitotic cells. Decreases in the remnant liver weights and mitotic indices were more extensive in the malnourished rats. Additionally, malnutrition was associated with low plasma IGF-I concentrations following partial hepatectomy. IGF-I administration was not associated with an improved nitrogen balance following hepatectomy. These results suggest that an adequate nutritional status is essential for liver regeneration, and that malnutrition is associated with lower plasma IGF-I concentrations following partial hepatectomy. An inadequate nutrient supply may abolish the anabolic effect of the administration of IGF-I on nutritional repletion postoperatively.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 42, 号 4, p. 159-163, 発行日 1994-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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