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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.43 No.3

Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer

http://hdl.handle.net/10191/33212
b668fd24-24b5-4e1d-9eb0-c14acba909d1
名前 / ファイル ライセンス アクション
43(3)_147-150.pdf 43(3)_147-150.pdf (448.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-31
タイトル
タイトル Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer
タイトル
言語 en
タイトル Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer
言語
言語 eng
キーワード
主題Scheme Other
主題 HNPCC
キーワード
主題Scheme Other
主題 early cancer
キーワード
主題Scheme Other
主題 morphogenesis
キーワード
主題Scheme Other
主題 adenoma-carcinoma sequence
キーワード
主題Scheme Other
主題 de novo cancer
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Jass, Jeremy R.

× Jass, Jeremy R.

WEKO 53060

Jass, Jeremy R.

Search repository
抄録
内容記述タイプ Abstract
内容記述 An understanding of the early morphogenesis of hereditary non-polyposis colorectal cancer (HNPCC) is relevant to screening strategies. If most cancers in HNPCC were to evolve through the classical adenoma-carcinoma sequence, screening and removal of adenomas at relatively long intervals might be a safe and cost-effective approach. 131 cancers from 117 affected members of 34 HNPCC families were reviewed. 104 cancers were initial symptomatic lesions, eight were cancers detected in asymptomatic screened individuals, one was a synchronous cancer and 18 were metachronous cancers. None of the 131 cancers was a small, superficial type. Residual adenoma was present in 3/3 (100%) in-situ cancers, 8/9 (89%) cancers involving only submucosa, 4/14 (29%) cancers limited to the muscle coat and 13/105 (12%) cancers extending beyond the muscle coat. 21/28 (75%) residual adenomas had a villous component. Only one was flat. Of the eight asymptomatic cancers, seven arose within tubular or tubulovillous adenomas. The eighth was not associated with an adenoma but was 35 mm in diameter and extended through the bowel wall. Discrete adenomas (contiguous excluded) were present in 22% of surgical specimens and in 31% of specimens from subjects older than 50 years. A relatively high proportion (30%) had a villous component and 43% were at least 10 mm in diameter. Patients with one or more discrete adenoma in their first surgical specimen were more likely to develop multiple cancers. The findings are consistent with the view that adenomas do not occur with increased frequency in HNPCC but are more likely to be large and adopt a villous configuration. There is little evidence for morphogenetic pathways involving flat adenomas or de novo carcinoma in HNPCC.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 43, 号 3, p. 147-150, 発行日 1995-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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