{"_buckets": {"deposit": "d9a4c716-888b-49f1-b067-3508ee3983cf"}, "_deposit": {"id": "6465", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6465"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006465"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1995-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "150", "bibliographicPageStart": "147", "bibliographicVolumeNumber": "43", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "An understanding of the early morphogenesis of hereditary non-polyposis colorectal cancer (HNPCC) is relevant to screening strategies. If most cancers in HNPCC were to evolve through the classical adenoma-carcinoma sequence, screening and removal of adenomas at relatively long intervals might be a safe and cost-effective approach. 131 cancers from 117 affected members of 34 HNPCC families were reviewed. 104 cancers were initial symptomatic lesions, eight were cancers detected in asymptomatic screened individuals, one was a synchronous cancer and 18 were metachronous cancers. None of the 131 cancers was a small, superficial type. Residual adenoma was present in 3/3 (100%) in-situ cancers, 8/9 (89%) cancers involving only submucosa, 4/14 (29%) cancers limited to the muscle coat and 13/105 (12%) cancers extending beyond the muscle coat. 21/28 (75%) residual adenomas had a villous component. Only one was flat. Of the eight asymptomatic cancers, seven arose within tubular or tubulovillous adenomas. The eighth was not associated with an adenoma but was 35 mm in diameter and extended through the bowel wall. Discrete adenomas (contiguous excluded) were present in 22% of surgical specimens and in 31% of specimens from subjects older than 50 years. A relatively high proportion (30%) had a villous component and 43% were at least 10 mm in diameter. Patients with one or more discrete adenoma in their first surgical specimen were more likely to develop multiple cancers. The findings are consistent with the view that adenomas do not occur with increased frequency in HNPCC but are more likely to be large and adopt a villous configuration. There is little evidence for morphogenetic pathways involving flat adenomas or de novo carcinoma in HNPCC.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Jass, Jeremy R."}], "nameIdentifiers": [{"nameIdentifier": "53060", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "43(3)_147-150.pdf", "filesize": [{"value": "448.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 448100.0, "url": {"label": "43(3)_147-150.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6465/files/43(3)_147-150.pdf"}, "version_id": "9bb7c35e-8a9d-4354-8866-abc842806af4"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "HNPCC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "early cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "morphogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenoma-carcinoma sequence", "subitem_subject_scheme": "Other"}, {"subitem_subject": "de novo cancer", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer"}, {"subitem_title": "Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/622"], "permalink_uri": "http://hdl.handle.net/10191/33212", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-31"}, "publish_date": "2015-08-31", "publish_status": "0", "recid": "6465", "relation": {}, "relation_version_is_last": true, "title": ["Hereditary Non-polyposis Colorectal Cancer as a Model for Early Colorectal Cancer"], "weko_shared_id": null}