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The Absence of Any Obvious Association of the Human Glucagon-Like Peptide-1 (GLP-1) Receptor Gene Simple Tandem Repeat Polymorphism with NIDDM
http://hdl.handle.net/10191/33157
http://hdl.handle.net/10191/3315789c39488-b79d-4e7a-9cd4-14b09699159b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44(1)_43-45.pdf (534.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-27 | |||||
| タイトル | ||||||
| タイトル | The Absence of Any Obvious Association of the Human Glucagon-Like Peptide-1 (GLP-1) Receptor Gene Simple Tandem Repeat Polymorphism with NIDDM | |||||
| タイトル | ||||||
| タイトル | The Absence of Any Obvious Association of the Human Glucagon-Like Peptide-1 (GLP-1) Receptor Gene Simple Tandem Repeat Polymorphism with NIDDM | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glucagon-like peptide-1(GLP-1) receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | simple tandem repeat polymorphism (STRP) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NIDDM | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Daimon, Makoto
× Daimon, Makoto× Yamatani, Keiichi× Igarashi, Masahiko× Fukase, Norio× Ikezawa, Yoshihiro× Manaka, Hideo× Tominaga, Makoto× Sasaki, Hideo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Glucagon-like peptide-1 (GLP-1) has a potent glucose-dependent insulin secretory effect, and is thought to play an important role in regulating blood glucose levels as an "Incretin". In the early stage of non-insulindependent diabetes mellitus (NIDDM), impaired glucose-regulated insulin secretion in the rapid phase is a common feature. This feature is regarded to be partly due to defects in the biological actions of GLP-1, which are mediated by the GLP-1 receptor. Thus, defects in the islet B cell GLP-1 receptor gene may contribute to NIDDM. To test this hypothesis, we examined the association of the reported simple tandem repeat polymorphism (STRP) in GLP-1 receptor gene with NIDDM in Japanese. Genomic DNAs were extracted from peripheral blood leukocytes obtained from 24 independent NIDDM patients as well as 31 independent normal control subjects. The DNA fragments containing the reported STRP region were amplified by PCR. The sizes of the amplified DNA fragments varied between 108 to 122 bp (corresponding to 17 to 24 CA repeats); accordingly 8 different alleles were observed. The allelic frequencies did not differ between the Japanese NIDDM patients and the control subjects. These results indicate the absence of any obvious association of GLP-1 receptor gene STRP with NIDDM in Japanese. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 1, p. 43-45, 発行日 1996-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
