WEKO3
アイテム
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Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)
http://hdl.handle.net/10191/33163
http://hdl.handle.net/10191/33163b3083ca6-cf0a-461c-b296-55c570a61410
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cisplatin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multidrug resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovarian cancer cell line | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Kamishima, Tomoko
× Kamishima, Tomoko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cis-diamminedichloroplatinum (II) (CDDP) resistant-human ovarian cancer cell line (TYK-R10) was examined for its drug resistance to other anti-cancer drugs, and growth response to various growth factors, compared with the parental cell line (TYK-nu). TYK-R10 was established by a gradual increase in the concentrations of CDDP compared with the parental line. TYK-R10 showed about a ten-fold resistance, with 1×10^<-5> M CDDP of IC_<50>, which represents the concentration of an anti-cancer drug to produce a 50% inhibition of cell growth. TYK-R10 revealed a cross resistance to various anti-cancer drugs including carboplatin (CBDCA), vincristin (VCR) and adriamycin (ADR). However, no significant alternations in topoisomerase II, glutathione-S-transferase levels or glutathione concentrations were detected. In addition, P-glycoprotein (P-gp) was not expressed on the cell surface of TYK-R10 and verapamil had no reverse effect on resistance to CDDP, CBDCA, VCR and ADR. Surface marker analysis using epidermal growth factor receptor antibody disclosed a high positivity in TYK-R10, compared with TYK-nu, and consequently epidermal growth factor activated the growth of TYK-R10. Transforming growth factor α had no effect on the growth of TYK-R10, whereas it promoted the growth of TYK-nu. In contrast, transforming growth factor β promoted the growth of TYK-nu, whereas it inhibited the growth of TYK-R10. These results indicate that the mechanism of multidrug resistance of TYK-R10 is not mediated through P-gp, and that altered responsibility for some growth factor in TYK-R10 is closely associated with the acquisition of CDDP resistance. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 2, p. 79-86, 発行日 1996-06 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |