{"_buckets": {"deposit": "bf32dfda-f5f0-4cf8-a4f0-0fb1dd9fd15d"}, "_deposit": {"id": "6436", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6436"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006436"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "86", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Cis-diamminedichloroplatinum (II) (CDDP) resistant-human ovarian cancer cell line (TYK-R10) was examined for its drug resistance to other anti-cancer drugs, and growth response to various growth factors, compared with the parental cell line (TYK-nu). TYK-R10 was established by a gradual increase in the concentrations of CDDP compared with the parental line. TYK-R10 showed about a ten-fold resistance, with 1\u00d710^\u003c-5\u003e M CDDP of IC_\u003c50\u003e, which represents the concentration of an anti-cancer drug to produce a 50% inhibition of cell growth. TYK-R10 revealed a cross resistance to various anti-cancer drugs including carboplatin (CBDCA), vincristin (VCR) and adriamycin (ADR). However, no significant alternations in topoisomerase II, glutathione-S-transferase levels or glutathione concentrations were detected. In addition, P-glycoprotein (P-gp) was not expressed on the cell surface of TYK-R10 and verapamil had no reverse effect on resistance to CDDP, CBDCA, VCR and ADR. Surface marker analysis using epidermal growth factor receptor antibody disclosed a high positivity in TYK-R10, compared with TYK-nu, and consequently epidermal growth factor activated the growth of TYK-R10. Transforming growth factor \u03b1 had no effect on the growth of TYK-R10, whereas it promoted the growth of TYK-nu. In contrast, transforming growth factor \u03b2 promoted the growth of TYK-nu, whereas it inhibited the growth of TYK-R10. These results indicate that the mechanism of multidrug resistance of TYK-R10 is not mediated through P-gp, and that altered responsibility for some growth factor in TYK-R10 is closely associated with the acquisition of CDDP resistance.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kamishima, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "52917", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "44(2)_79-86.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "44(2)_79-86.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6436/files/44(2)_79-86.pdf"}, "version_id": "226ee824-1575-4951-8223-3478b394589f"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "cisplatin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "multidrug resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "growth factors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ovarian cancer cell line", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)"}, {"subitem_title": "Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/619"], "permalink_uri": "http://hdl.handle.net/10191/33163", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-27"}, "publish_date": "2015-08-27", "publish_status": "0", "recid": "6436", "relation": {}, "relation_version_is_last": true, "title": ["Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)"], "weko_shared_id": null}